Home Endocrinology & Hormones Glucocorticoid Receptor agonist - Estrogen/progestogen Receptor agonist (20S)-Protopanaxatriol For research use only.

(20S)-Protopanaxatriol

Synonyms: g-PPT, 20(S)-APPT

(20S)-Protopanaxatriol (g-PPT, 20(S)-APPT), a neuroprotective metabolite of ginsenoside, protopanaxatriol (g-PPT), is a functional ligand for both GR and ERbeta and could modulate endothelial cell functions through the glucocorticoid receptor (GR) and estrogen receptor (ER).

(20S)-Protopanaxatriol Chemical Structure

(20S)-Protopanaxatriol Chemical Structure

CAS No. 34080-08-5

Purity & Quality Control

Batch: S361701 DMSO]95 mg/mL]false]Ethanol]95 mg/mL]false]Water]Insoluble]false Purity: 99.43%
99.43

(20S)-Protopanaxatriol Related Products

Biological Activity

Description (20S)-Protopanaxatriol (g-PPT, 20(S)-APPT), a neuroprotective metabolite of ginsenoside, protopanaxatriol (g-PPT), is a functional ligand for both GR and ERbeta and could modulate endothelial cell functions through the glucocorticoid receptor (GR) and estrogen receptor (ER).
In vitro
In vitro Protopanaxtriol (Ppt) is a neuroprotective ginseng extract. Ppt exerts its antioxidative activity via several mechanisms, such as direct scavenging of free radicals and restoration of succinate dehydrogenase activity. These mechanisms may contribute to its potent antioxidative and putative neuroprotective activities[1]. Ppt exhibited strong noncompetitive inhibition towards UGT1A1 and competitive inhibition towards UGT2B7. The inhibition kinetic parameters (Ki) were calculated to be 8.8 and 2.2 μM for UGT1A1 and UGT2B7, respectively[2]. PPT could repress the viability and invasiveness, and promote the apoptosis in A549 and SK-MES-1 cells.
Cell Research Cell lines A549 cells or SK-MES-1 cells
Concentrations 0, 0.4, 4 or 40 uM
Incubation Time 48 h
Method A549 cells or SK-MES-1 cells are seeded in 96-well plates (3×103 cells/well), and then treated with different concentration of PPD, PPT, G-Rg3 or G-Rh2 (0, 0.4, 4 or 40 μM) for 48 h, with cisplatin (2 ug/ml) as a positive control and 0.1% DMSO as a blank control. Then these cells are collected and detected the viability by the cell-counting Kit-8 (CCK-8) assay.
In Vivo
In vivo Protopanaxtriol (Ppt) is shown to reduce learning and memory impairment associated with Alzheimer's diseases and protect against 3-NP-induced oxidative stressin the rat model of Huntington's disease, which is associated with its anti-oxidant activity. Ppt prevents short- and long-term memory impairments induced by chronic sleep deprivation probably through antagonizing oxidative stress in the cortex and hippocampus[1].
Animal Research Animal Models ICR male mice
Dosages 20μmol/kg, 40μmol/kg
Administration i.p.

Chemical Information & Solubility

Molecular Weight 476.73 Formula

C30H52O4
CAS No. 34080-08-5 SDF Download (20S)-Protopanaxatriol SDF
Smiles CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CC(C4C3(CCC(C4(C)C)O)C)O)C)O)C)O)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 95 mg/mL ( (199.27 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 95 mg/mL

Water : Insoluble


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In vivo
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