Home Angiogenesis Src inhibitor - CDK inhibitor - CaMK inhibitor - Bcr-Abl inhibitor 1-NM-PP1 For research use only.

1-NM-PP1

Synonyms: PP1 Analog II, 1NM-PP1

1-NM-PP1 (PP1 Analog II, 1NM-PP1, analogue 9) is a potent inhibitor of Src family kinases with IC50 of 4.3 nM and 3.2 nM for v-Src-as1 and c-Fyn-as1, respectively. 1-NM-PP1 also inhibits CDK2-as1, CAMKII-as1 and c-Abl-as2 with IC50 of 5.0 nM, 8.0 nM and 120 nM, respectively.

1-NM-PP1 Chemical Structure

1-NM-PP1 Chemical Structure

CAS No. 221244-14-0

Purity & Quality Control

Batch: S638301 DMSO]66 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.35%
99.35

1-NM-PP1 Related Products

Signaling Pathway

Src Signaling Pathways

Src Signaling Pathway

Biological Activity

Description 1-NM-PP1 (PP1 Analog II, 1NM-PP1, analogue 9) is a potent inhibitor of Src family kinases with IC50 of 4.3 nM and 3.2 nM for v-Src-as1 and c-Fyn-as1, respectively. 1-NM-PP1 also inhibits CDK2-as1, CAMKII-as1 and c-Abl-as2 with IC50 of 5.0 nM, 8.0 nM and 120 nM, respectively.
Targets
c-Fyn-as1 [1]
(Cell-free assay)		 v-Src-as1 [1]
(Cell-free assay)		 CDK2-as1 [1]
(Cell-free assay)		 CAMKII-as1 [1]
(Cell-free assay)		 c-Abl-as2 [1]
(Cell-free assay)
3.2 nM 4.3 nM 5.0 nM 8.0 nM 120 nM

Chemical Information & Solubility

Molecular Weight 331.41 Formula

C20H21N5
CAS No. 221244-14-0 SDF --
Smiles CC(C)(C)[N]1N=C(CC2=CC=CC3=CC=CC=C23)C4=C(N)N=CN=C14
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 66 mg/mL ( (199.14 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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