Home GPCR & G Protein GluR chemical (R,S)-3,5-DHPG Hydrochloride For research use only.

(R,S)-3,5-DHPG Hydrochloride

Synonyms: DHPG, Dihydroxy phenylglycine

(R,S)-3,5-DHPG hydrochloride (DHPG, Dihydroxy phenylglycine) is a salt of free amino acid dihydroxy phenylglycine (DHPG) which acts as a selective and potent agonist of group I metabotropic glutamate receptors (mGluR) (mGluR 1 and mGluR 5).

(R,S)-3,5-DHPG Hydrochloride Chemical Structure

(R,S)-3,5-DHPG Hydrochloride Chemical Structure

CAS No. 19641-83-9

Purity & Quality Control

Batch: E125701 DMSO]44 mg/mL]false]Water]44 mg/mL]false]Ethanol]22 mg/mL]false Purity: 99.07%
99.07

(R,S)-3,5-DHPG Hydrochloride Related Products

Signaling Pathway

GluR Signaling Pathways

GluR Signaling Pathway

Biological Activity

Description (R,S)-3,5-DHPG hydrochloride (DHPG, Dihydroxy phenylglycine) is a salt of free amino acid dihydroxy phenylglycine (DHPG) which acts as a selective and potent agonist of group I metabotropic glutamate receptors (mGluR) (mGluR 1 and mGluR 5).
Targets
mGluR [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03154359 Completed
ADHD
Children''s Mercy Hospital Kansas City|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
 December 12 2017 --
NCT02428088 Completed
Attention Deficit Hyperactivity Disorder
Sumitomo Pharma America Inc.
 April 2015 Phase 2|Phase 3

Chemical Information & Solubility

Molecular Weight 219.62 Formula

C8H9NO4
CAS No. 19641-83-9 SDF --
Smiles Cl.NC(C(O)=O)C1=CC(=CC(=C1)O)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 44 mg/mL ( (200.34 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 44 mg/mL

Ethanol : 22 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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