PORCN

PORCN Products

All (6)
PORCN Inhibitors (6)
New PORCN Products

Catalog No.	Product Name	Information	Product Use Citations
S7037	Wnt-C59 (C59)	Wnt-C59 (C59) is a PORCN inhibitor for Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferase with IC50 of 74 pM in HEK293 cells.	Adv Mater, 2024, e2400364. Nat Commun, 2024, 15(1):1487 Nat Commun, 2024, 15(1):2137
S7143	LGK-974	LGK-974 (NVP-LGK974, WNT974) is a potent and specific PORCN inhibitor, and inhibits Wnt signaling with IC50 of 0.4 nM in TM3 cells. Phase 1.	Nat Commun, 2024, 15(1):7404 J Exp Med, 2024, 221(10)e20232279 EMBO J, 2024, 43(16):3388-3413
S7301	IWP-L6	IWP-L6 (Porcn Inhibitor III) is a highly potent Porcn inhibitor with EC50 of 0.5 nM.	iScience, 2022, 25(10):105182 Sci Rep, 2022, 12(1):7 Carcinogenesis, 2020, 41(7):993-1004
S6616	ETC-159	ETC-159 (ETC-1922159) is an orally available, potent porcupine inhibitor with an IC50 of 2.9 nM for inhibiting β-catenin reporter activity in STF3A cells.	Nat Commun, 2023, 14(1):2402 J Pathol, 2022, 10.1002/path.5868
S8645	IWP-O1	IWP-O1 is a porcn inhibitor with an EC50 value of 80 pM in a cultured cell reporter assay of Wnt signaling and effectively suppresses the phosphorylation of Dvl2/3 in HeLa cells.	Cancer Cell, 2022, S1535-6108(21)00662-0
S8644	GNF-6231	GNF-6231 is a potent, orally active and selective Porcupine inhibitor with IC50 of 0.8 nM.
S7037	Wnt-C59 (C59)	Wnt-C59 (C59) is a PORCN inhibitor for Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferase with IC50 of 74 pM in HEK293 cells.	Adv Mater, 2024, e2400364. Nat Commun, 2024, 15(1):1487 Nat Commun, 2024, 15(1):2137
S7143	LGK-974	LGK-974 (NVP-LGK974, WNT974) is a potent and specific PORCN inhibitor, and inhibits Wnt signaling with IC50 of 0.4 nM in TM3 cells. Phase 1.	Nat Commun, 2024, 15(1):7404 J Exp Med, 2024, 221(10)e20232279 EMBO J, 2024, 43(16):3388-3413
S7301	IWP-L6	IWP-L6 (Porcn Inhibitor III) is a highly potent Porcn inhibitor with EC50 of 0.5 nM.	iScience, 2022, 25(10):105182 Sci Rep, 2022, 12(1):7 Carcinogenesis, 2020, 41(7):993-1004
S6616	ETC-159	ETC-159 (ETC-1922159) is an orally available, potent porcupine inhibitor with an IC50 of 2.9 nM for inhibiting β-catenin reporter activity in STF3A cells.	Nat Commun, 2023, 14(1):2402 J Pathol, 2022, 10.1002/path.5868
S8645	IWP-O1	IWP-O1 is a porcn inhibitor with an EC50 value of 80 pM in a cultured cell reporter assay of Wnt signaling and effectively suppresses the phosphorylation of Dvl2/3 in HeLa cells.	Cancer Cell, 2022, S1535-6108(21)00662-0
S8644	GNF-6231	GNF-6231 is a potent, orally active and selective Porcupine inhibitor with IC50 of 0.8 nM.

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