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PFKFB

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Catalog No. Product Name Information Product Use Citations Product Validations
S7289 PFK15 PFK15 (PFK-015) is a potent and selective 6-phosphofructo-2-kinase (PFKFB3) inhibitor with IC50 of 207 nM.
Clin Exp Med, 2024, 24(1):219
Eur J Med Res, 2024, 29(1):236
Nat Commun, 2023, 14(1):5552
S7639 3PO 3PO (3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one) is a small-molecule inhibitor of PFKFB3 with an IC50 of 22.9 μM for recombinant human PFKFB3 protein and does not inhibit PFK-1 activity. It suppresses glucose uptake, and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+, and NADH.
Respir Res, 2022, 23(1):75
Am J Transl Res, 2022, 14(10):7552-7565
Exp Neurol, 2021, 347:113871
S8807 PFK158 PFK158 is a potent and selective inhibitor of PFKFB3. It has improved PK properties and causes ~80% growth inhibition in several mouse models of human-derived tumors.
Nat Metab, 2022, 4(10):1287-1305
Cancers (Basel), 2022, 14(9)2113
Front Oncol, 2022, 12:826655
S0400 KAN0438757 KAN0438757 is a potent and selective inhibitor of the metabolic kinase PFKFB3 (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3) with IC50 of 0.19 μM and 3.6 μM for PFKFB3 and PFKFB4, respectively.
Mol Cell Proteomics, 2023, 22(11):100649
Mol Cell Proteomics, 2023, 10.1016/j.mcpro.2023.100649
S7289 PFK15 PFK15 (PFK-015) is a potent and selective 6-phosphofructo-2-kinase (PFKFB3) inhibitor with IC50 of 207 nM.
Clin Exp Med, 2024, 24(1):219
Eur J Med Res, 2024, 29(1):236
Nat Commun, 2023, 14(1):5552
S7639 3PO 3PO (3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one) is a small-molecule inhibitor of PFKFB3 with an IC50 of 22.9 μM for recombinant human PFKFB3 protein and does not inhibit PFK-1 activity. It suppresses glucose uptake, and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+, and NADH.
Respir Res, 2022, 23(1):75
Am J Transl Res, 2022, 14(10):7552-7565
Exp Neurol, 2021, 347:113871
S8807 PFK158 PFK158 is a potent and selective inhibitor of PFKFB3. It has improved PK properties and causes ~80% growth inhibition in several mouse models of human-derived tumors.
Nat Metab, 2022, 4(10):1287-1305
Cancers (Basel), 2022, 14(9)2113
Front Oncol, 2022, 12:826655
S0400 KAN0438757 KAN0438757 is a potent and selective inhibitor of the metabolic kinase PFKFB3 (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3) with IC50 of 0.19 μM and 3.6 μM for PFKFB3 and PFKFB4, respectively.
Mol Cell Proteomics, 2023, 22(11):100649
Mol Cell Proteomics, 2023, 10.1016/j.mcpro.2023.100649

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