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SN 52

Catalog No.P1238 Purity: 99.01%

SN52, a cell-permeable peptide containing the p50 NLS, is a selective inhibitor of NF-κB pathway. It selectively and completely blocks the ionizing radiation (IR)-induced nuclear import of p52 and RelB. It also enhances the radiosensitivity of prostate cancer cells.

Amino-acid Sequence

CAS No. 1071173-56-2

Purity & Quality Control

Batch: P123801 Water] 100 mg/mL] false] DMSO] Insoluble] false] Ethanol] Insoluble] false Purity: 99.01%

99.01

Chemical Information & Solubility

Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
			1 month-20°Cin solvent

In vitro
Batch:

Water : 100 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Biological Activity

Description	SN52, a cell-permeable peptide containing the p50 NLS, is a selective inhibitor of NF-κB pathway. It selectively and completely blocks the ionizing radiation (IR)-induced nuclear import of p52 and RelB. It also enhances the radiosensitivity of prostate cancer cells.

References

[1] Xu Y, et al. Mol Cancer Ther. 2008 Aug;7(8):2367-76.

Product Information

Molecular Formula:	C₁₂₈H₂₃₀N₃₈O₂₈
Molecular Weight:	2749.44
CAS No.:	1071173-56-2
Shipping:	Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)