Home Peptide Products JNJ-77242113(Icotrokinra) For research use only. Not for use in humans.

JNJ-77242113(Icotrokinra)

Icotrokinra (JNJ-77242113, JNJ-2113, PN-235) is an orally available and selective antagonist of the IL-23 receptor. It also inhibits IL-23–induced STAT3 phosphorylation in peripheral blood mononuclear cells with an IC50 of 5.6 pM and suppresses IL-23–induced IFN-γ production in NK cells with an IC50 of 18.4 pM. It also exhibits anti-inflammatory activity in a TNBS-induced colitis model in rats and holds potential for studying psoriasis, psoriatic arthritis, and inflammatory bowel disease.

Amino-acid Sequence

JNJ-77242113(Icotrokinra) Amino-acid Sequence

CAS No. 2763602-16-8

Purity & Quality Control

Batch: P125201 DMSO] 100 mg/mL] false] Water] 100 mg/mL] false] Ethanol] 3 mg/mL] false Purity: 99.56%
99.56

Chemical Information & Solubility

Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (52.68 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : 3 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Biological Activity

Description Icotrokinra (JNJ-77242113, JNJ-2113, PN-235) is an orally available and selective antagonist of the IL-23 receptor. It also inhibits IL-23–induced STAT3 phosphorylation in peripheral blood mononuclear cells with an IC50 of 5.6 pM and suppresses IL-23–induced IFN-γ production in NK cells with an IC50 of 18.4 pM. It also exhibits anti-inflammatory activity in a TNBS-induced colitis model in rats and holds potential for studying psoriasis, psoriatic arthritis, and inflammatory bowel disease.

Product Information

Molecular Formula:

C90H120N20O22S2
Molecular Weight: 1898.17
CAS No.: 2763602-16-8
Shipping: Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)