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Apamin

Apamin, an 18 amino acid peptide neurotoxin present in apitoxin (bee venom), has been shown to have anti-inflammatory and anti-fibrotic properties. It is known to be a highly selective blocker of Ca2+-activated K+ (SK) channels and then lessen the expression of α-SMA in the TGF-β1-induced HSC-T6 cells.

Amino-acid Sequence

Apamin Amino-acid Sequence

CAS No. 24345-16-2

Purity & Quality Control

Batch: Purity: 99.93%
99.93

Chemical Information & Solubility

Storage (From the date of receipt) 3 years-20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (49.32 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Biological Activity

Description Apamin, an 18 amino acid peptide neurotoxin present in apitoxin (bee venom), has been shown to have anti-inflammatory and anti-fibrotic properties. It is known to be a highly selective blocker of Ca2+-activated K+ (SK) channels and then lessen the expression of α-SMA in the TGF-β1-induced HSC-T6 cells.
Targets
Potassium channel

Product Information

Molecular Formula:

C79H131N31O24S4
Molecular Weight: 2027.35
CAS No.: 24345-16-2
Appearance: White Powder
Peptide Content (by %N): ≥80%
Single Impurity (by HPLC): ≤1.0%
Assay (By Anhydrous, Acetic Acid-free): 95.0~105.0%
MS: Consistent
Packing: plastic vial(dedicated for peptide packing) or glass vial, quantity according to customer's detail requirement.
Storage
(From the date of receipt):		 3 years -20°C powder； 1 years -80°C in solvent
Shipping: Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)