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NUDIX

Isoform-selective Products

NUDIX1

NUDIX Products

All (5)
NUDIX Inhibitors (5)
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Catalog No.	Product Name	Information	Product Use Citations	Product Validations
S7505	(S)-crizotinib	(S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM in a cell-free assay.	Bio Protoc, 2023, 10.21769/BioProtoc.4870 Am J Respir Crit Care Med, 2020, 10.1164/rccm.202003-0627OC Antiviral Res, 2020, 178:104790
S7632	TH588	TH588 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 5 nM. It has no relevant inhibition of any of the other tested proteins at 100 μM, although TH588 showed reasonable selectivity when tested on a much larger panel of 87 enzymes, GPCRs, kinases, ion channels and transporters at 10 μM.	Adv Healthc Mater, 2024, e2402349. Colloids Surf B Biointerfaces, 2022, 218:112715 Cell Syst, 2019, 9(1):74-92.e8
S7631	TH287	TH287 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 0.8 nM.	Nat Commun, 2024, 15(1):2377 Breast Cancer Res, 2022, 24(1):41 Oncogene, 2021, 10.1038/s41388-021-02105-9
E1274	TH1760	TH1760 (Compound 18) is a first-in-class, potent, selective and cell-active NUDT15 (MTH2) inhibitor with an IC50 value of 25 nM.
E2849	TH5427	TH5427 is a potent and cell-active NUDT5 (also called NUDIX5) inhibitor that can be used to further understand the role of NUDT5 in biological systems.
S7505	(S)-crizotinib	(S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM in a cell-free assay.	Bio Protoc, 2023, 10.21769/BioProtoc.4870 Am J Respir Crit Care Med, 2020, 10.1164/rccm.202003-0627OC Antiviral Res, 2020, 178:104790
S7632	TH588	TH588 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 5 nM. It has no relevant inhibition of any of the other tested proteins at 100 μM, although TH588 showed reasonable selectivity when tested on a much larger panel of 87 enzymes, GPCRs, kinases, ion channels and transporters at 10 μM.	Adv Healthc Mater, 2024, e2402349. Colloids Surf B Biointerfaces, 2022, 218:112715 Cell Syst, 2019, 9(1):74-92.e8
S7631	TH287	TH287 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 0.8 nM.	Nat Commun, 2024, 15(1):2377 Breast Cancer Res, 2022, 24(1):41 Oncogene, 2021, 10.1038/s41388-021-02105-9
E1274	TH1760	TH1760 (Compound 18) is a first-in-class, potent, selective and cell-active NUDT15 (MTH2) inhibitor with an IC50 value of 25 nM.
E2849	TH5427	TH5427 is a potent and cell-active NUDT5 (also called NUDIX5) inhibitor that can be used to further understand the role of NUDT5 in biological systems.

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