HMG-CoA Reductase

HMG-CoA Reductase Products

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  • HMG-CoA Reductase Inhibitors (16)
  • New HMG-CoA Reductase Products
Catalog No. Product Name Information Product Use Citations Product Validations
S1792 Simvastatin Simvastatin is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM in cell-free assays. Simvastatin induces ferroptosis, mitophagy, autophagy and apoptosis.
Cancer Med, 2024, 13(12):e7393
Neuron, 2023, S0896-6273(23)00513-5
Cancer Res, 2023, 83(13):2248-2261
S2061 Lovastatin Lovastatin is an inhibitor of HMG-CoA reductase with IC50 of 3.4 nM in a cell-free assay, used for lowering cholesterol (hypolipidemic agent). Lovastatin triggers autophagy.
Cell Discov, 2024, 10(1):39
Int J Biol Sci, 2024, 20(6):2130-2148
Int J Biol Sci, 2024, 20(6):2130-2148
S1909 Fluvastatin Sodium Fluvastatin Sodium inhibits HMG-CoA reductase activity with IC50 of 8 nM in a cell-free assay.
Oncogene, 2022, 41(39):4446-4458
iScience, 2022, 25(10):105068
BMC Cancer, 2022, 22(1):282
S5715 Atorvastatin Atorvastatin is a lipid lowering agent. It is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway. Atorvastatin activates autophagy.
MedComm (2020), 2024, 5(5):e525
Oncogene, 2024, 43(4):281-293
Mol Cancer, 2023, 22(1):147
S1759 Pitavastatin calcium Pitavastatin calcium, a novel member of the medication class of statins, is a calcium salt formulation of pitavastatin which is a highly effective HMG-CoA reductase inhibitor. Pitavastatin Calcium attenuates AGEs-induced mitophagy via inhibition of ROS generation. Pitavastatin Calcium induces autophagy and apoptosis.
Nat Commun, 2024, 15(1):4099
Cell Rep, 2024, 43(6):114286
bioRxiv, 2024, 2024.02.02.578510
S2169 Rosuvastatin calcium Rosuvastatin calcium is a competitive inhibitor of HMG-CoA reductase with IC50 of 11 nM in a cell-free assay.
bioRxiv, 2024, 10.1101/2024.01.16.575899
Neuron, 2023, S0896-6273(23)00513-5
Int J Mol Sci, 2023, 24(9)8359
S2077 Atorvastatin Calcium Atorvastatin Calcium is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol. Atorvastatin Calcium induces apoptosis and autophagy.
Cancers (Basel), 2022, 14(9)2327
Nat Biotechnol, 2021, 10.1038/s41587-021-00860-4
Neurobiol Dis, 2021, 152:105294
S3036 Pravastatin sodium Pravastatin sodium (CS-514) is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.
Int J Mol Sci, 2023, 24(7)6500
J Cosmet Dermatol, 2022, 10.1111/jocd.15142
Nat Biotechnol, 2021, 10.1038/s41587-021-00860-4
S4223 Mevastatin Mevastatin (ML-236B,Compactin) is a competitive inhibitor of HMG-Coenzyme A (HMG-CoA) reductase with a binding affinity 10,000 times greater than the HMG-CoA substrate itself.
Nat Cardiovasc Res, 2023, 2(6):550-571
Immunity, 2021, 54(10):2273-2287.e6
Front Pharmacol, 2020, 11:574068
S5713 Pravastatin Pravastatin(CS-514) is a lipoprotein-lowering drug via reversibly inhibiting hydroxymethylglutaryl-CoA (HMG-CoA) reductase and the synthesis of very-low-density lipoproteins.
EMBO Rep, 2022, e53373
Biomedicines, 2022, 10(9)2123
Front Cardiovasc Med, 2022, 9:921829
S2664 Clinofibrate Clinofibrate inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR) with IC50 of 0.47 mM, is a lipid-lowering agent used for controlling high cholesterol and triacylglyceride levels in the blood.
Carcinogenesis, 2020, 7;bgaa036
S8302 SR-12813 SR-12813 is a pregnane X receptor (PXR) agonist and HMG-CoA reductase inhibitor with an IC50 of 850 nM.
Cell Death Dis, 2019, 10(10):777
E4821New Simvastatin acid (ammonium) Simvastatin acid (Tenivastatin) ammonium is a potent inhibitor of HMG-CoA reductase (HMGCR). Simvastatin acid ammonium also decreases Indoxyl sulfate-induced reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium regulates the expression of OATP3A1 in cardiomyocytes.
E1341New Cerivastatin sodium Cerivastatin sodium, a sodium salt of cerivastatin, is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase with Ki of 1.3 nM. It is also a synthetic, enantiomerically pure, pyridine derivative that effectively reduces serum cholesterol levels at microgram doses.
E2286 Dihydrolanosterol Dihydrolanosterol (24,25-Dihydrolanosterol; Dihydrolanosterin; Lanostenol) inhibits cholesterol biosynthesis by promoting ubiquitination and degradation of HMG CoA reductase.
E2741New 7-ketocholesterol 7-Ketocholesterol (7-Oxocholesterol), is a bioactive sterol and prominent cholesterol oxidation product, is a strong inhibitor of HMG-CoA reductase and cytochrome P450 7A1. It enhances oxidative stress, endoplasmic reticulum stress, and apoptosis in macrophages.
S1792 Simvastatin Simvastatin is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM in cell-free assays. Simvastatin induces ferroptosis, mitophagy, autophagy and apoptosis.
Cancer Med, 2024, 13(12):e7393
Neuron, 2023, S0896-6273(23)00513-5
Cancer Res, 2023, 83(13):2248-2261
S2061 Lovastatin Lovastatin is an inhibitor of HMG-CoA reductase with IC50 of 3.4 nM in a cell-free assay, used for lowering cholesterol (hypolipidemic agent). Lovastatin triggers autophagy.
Cell Discov, 2024, 10(1):39
Int J Biol Sci, 2024, 20(6):2130-2148
Int J Biol Sci, 2024, 20(6):2130-2148
S1909 Fluvastatin Sodium Fluvastatin Sodium inhibits HMG-CoA reductase activity with IC50 of 8 nM in a cell-free assay.
Oncogene, 2022, 41(39):4446-4458
iScience, 2022, 25(10):105068
BMC Cancer, 2022, 22(1):282
S5715 Atorvastatin Atorvastatin is a lipid lowering agent. It is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway. Atorvastatin activates autophagy.
MedComm (2020), 2024, 5(5):e525
Oncogene, 2024, 43(4):281-293
Mol Cancer, 2023, 22(1):147
S1759 Pitavastatin calcium Pitavastatin calcium, a novel member of the medication class of statins, is a calcium salt formulation of pitavastatin which is a highly effective HMG-CoA reductase inhibitor. Pitavastatin Calcium attenuates AGEs-induced mitophagy via inhibition of ROS generation. Pitavastatin Calcium induces autophagy and apoptosis.
Nat Commun, 2024, 15(1):4099
Cell Rep, 2024, 43(6):114286
bioRxiv, 2024, 2024.02.02.578510
S2169 Rosuvastatin calcium Rosuvastatin calcium is a competitive inhibitor of HMG-CoA reductase with IC50 of 11 nM in a cell-free assay.
bioRxiv, 2024, 10.1101/2024.01.16.575899
Neuron, 2023, S0896-6273(23)00513-5
Int J Mol Sci, 2023, 24(9)8359
S2077 Atorvastatin Calcium Atorvastatin Calcium is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol. Atorvastatin Calcium induces apoptosis and autophagy.
Cancers (Basel), 2022, 14(9)2327
Nat Biotechnol, 2021, 10.1038/s41587-021-00860-4
Neurobiol Dis, 2021, 152:105294
S3036 Pravastatin sodium Pravastatin sodium (CS-514) is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.
Int J Mol Sci, 2023, 24(7)6500
J Cosmet Dermatol, 2022, 10.1111/jocd.15142
Nat Biotechnol, 2021, 10.1038/s41587-021-00860-4
S4223 Mevastatin Mevastatin (ML-236B,Compactin) is a competitive inhibitor of HMG-Coenzyme A (HMG-CoA) reductase with a binding affinity 10,000 times greater than the HMG-CoA substrate itself.
Nat Cardiovasc Res, 2023, 2(6):550-571
Immunity, 2021, 54(10):2273-2287.e6
Front Pharmacol, 2020, 11:574068
S5713 Pravastatin Pravastatin(CS-514) is a lipoprotein-lowering drug via reversibly inhibiting hydroxymethylglutaryl-CoA (HMG-CoA) reductase and the synthesis of very-low-density lipoproteins.
EMBO Rep, 2022, e53373
Biomedicines, 2022, 10(9)2123
Front Cardiovasc Med, 2022, 9:921829
S2664 Clinofibrate Clinofibrate inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR) with IC50 of 0.47 mM, is a lipid-lowering agent used for controlling high cholesterol and triacylglyceride levels in the blood.
Carcinogenesis, 2020, 7;bgaa036
S8302 SR-12813 SR-12813 is a pregnane X receptor (PXR) agonist and HMG-CoA reductase inhibitor with an IC50 of 850 nM.
Cell Death Dis, 2019, 10(10):777
E4821New Simvastatin acid (ammonium) Simvastatin acid (Tenivastatin) ammonium is a potent inhibitor of HMG-CoA reductase (HMGCR). Simvastatin acid ammonium also decreases Indoxyl sulfate-induced reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium regulates the expression of OATP3A1 in cardiomyocytes.
E1341New Cerivastatin sodium Cerivastatin sodium, a sodium salt of cerivastatin, is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase with Ki of 1.3 nM. It is also a synthetic, enantiomerically pure, pyridine derivative that effectively reduces serum cholesterol levels at microgram doses.
E2286 Dihydrolanosterol Dihydrolanosterol (24,25-Dihydrolanosterol; Dihydrolanosterin; Lanostenol) inhibits cholesterol biosynthesis by promoting ubiquitination and degradation of HMG CoA reductase.
E2741New 7-ketocholesterol 7-Ketocholesterol (7-Oxocholesterol), is a bioactive sterol and prominent cholesterol oxidation product, is a strong inhibitor of HMG-CoA reductase and cytochrome P450 7A1. It enhances oxidative stress, endoplasmic reticulum stress, and apoptosis in macrophages.
E4821New Simvastatin acid (ammonium) Simvastatin acid (Tenivastatin) ammonium is a potent inhibitor of HMG-CoA reductase (HMGCR). Simvastatin acid ammonium also decreases Indoxyl sulfate-induced reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium regulates the expression of OATP3A1 in cardiomyocytes.
E1341New Cerivastatin sodium Cerivastatin sodium, a sodium salt of cerivastatin, is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase with Ki of 1.3 nM. It is also a synthetic, enantiomerically pure, pyridine derivative that effectively reduces serum cholesterol levels at microgram doses.
E2741New 7-ketocholesterol 7-Ketocholesterol (7-Oxocholesterol), is a bioactive sterol and prominent cholesterol oxidation product, is a strong inhibitor of HMG-CoA reductase and cytochrome P450 7A1. It enhances oxidative stress, endoplasmic reticulum stress, and apoptosis in macrophages.

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Tags: HMG-CoA Reductase inhibitor|HMG-CoA Reductase agonist|HMG-CoA Reductase activator|HMG-CoA Reductase inducer|HMG-CoA Reductase antagonist|HMG-CoA Reductase signaling pathway|HMG-CoA Reductase assay kit