S1792 |
Simvastatin
|
Simvastatin is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM in cell-free assays. Simvastatin induces ferroptosis, mitophagy, autophagy and apoptosis. |
-
Cancer Med, 2024, 13(12):e7393
-
Neuron, 2023, S0896-6273(23)00513-5
-
Cancer Res, 2023, 83(13):2248-2261
|
|
S2061 |
Lovastatin
|
Lovastatin is an inhibitor of HMG-CoA reductase with IC50 of 3.4 nM in a cell-free assay, used for lowering cholesterol (hypolipidemic agent). Lovastatin triggers autophagy. |
-
Cell Discov, 2024, 10(1):39
-
Int J Biol Sci, 2024, 20(6):2130-2148
-
Int J Biol Sci, 2024, 20(6):2130-2148
|
|
S1909 |
Fluvastatin Sodium
|
Fluvastatin Sodium inhibits HMG-CoA reductase activity with IC50 of 8 nM in a cell-free assay. |
-
Oncogene, 2022, 41(39):4446-4458
-
iScience, 2022, 25(10):105068
-
BMC Cancer, 2022, 22(1):282
|
|
S5715 |
Atorvastatin
|
Atorvastatin is a lipid lowering agent. It is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway. Atorvastatin activates autophagy. |
-
MedComm (2020), 2024, 5(5):e525
-
Oncogene, 2024, 43(4):281-293
-
Mol Cancer, 2023, 22(1):147
|
|
S1759 |
Pitavastatin calcium
|
Pitavastatin calcium, a novel member of the medication class of statins, is a calcium salt formulation of pitavastatin which is a highly effective HMG-CoA reductase inhibitor. Pitavastatin Calcium attenuates AGEs-induced mitophagy via inhibition of ROS generation. Pitavastatin Calcium induces autophagy and apoptosis. |
-
Nat Commun, 2024, 15(1):4099
-
Cell Rep, 2024, 43(6):114286
-
bioRxiv, 2024, 2024.02.02.578510
|
|
S2169 |
Rosuvastatin calcium
|
Rosuvastatin calcium is a competitive inhibitor of HMG-CoA reductase with IC50 of 11 nM in a cell-free assay. |
-
bioRxiv, 2024, 10.1101/2024.01.16.575899
-
Neuron, 2023, S0896-6273(23)00513-5
-
Int J Mol Sci, 2023, 24(9)8359
|
|
S2077 |
Atorvastatin Calcium
|
Atorvastatin Calcium is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol. Atorvastatin Calcium induces apoptosis and autophagy. |
-
Cancers (Basel), 2022, 14(9)2327
-
Nat Biotechnol, 2021, 10.1038/s41587-021-00860-4
-
Neurobiol Dis, 2021, 152:105294
|
|
S3036 |
Pravastatin sodium
|
Pravastatin sodium (CS-514) is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM. |
-
Int J Mol Sci, 2023, 24(7)6500
-
J Cosmet Dermatol, 2022, 10.1111/jocd.15142
-
Nat Biotechnol, 2021, 10.1038/s41587-021-00860-4
|
|
S4223 |
Mevastatin
|
Mevastatin (ML-236B,Compactin) is a competitive inhibitor of HMG-Coenzyme A (HMG-CoA) reductase with a binding affinity 10,000 times greater than the HMG-CoA substrate itself. |
-
Nat Cardiovasc Res, 2023, 2(6):550-571
-
Immunity, 2021, 54(10):2273-2287.e6
-
Front Pharmacol, 2020, 11:574068
|
|
S5713 |
Pravastatin
|
Pravastatin(CS-514) is a lipoprotein-lowering drug via reversibly inhibiting hydroxymethylglutaryl-CoA (HMG-CoA) reductase and the synthesis of very-low-density lipoproteins. |
-
EMBO Rep, 2022, e53373
-
Biomedicines, 2022, 10(9)2123
-
Front Cardiovasc Med, 2022, 9:921829
|
|
S2664 |
Clinofibrate
|
Clinofibrate inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR) with IC50 of 0.47 mM, is a lipid-lowering agent used for controlling high cholesterol and triacylglyceride levels in the blood. |
-
Carcinogenesis, 2020, 7;bgaa036
|
|
S8302 |
SR-12813
|
SR-12813 is a pregnane X receptor (PXR) agonist and HMG-CoA reductase inhibitor with an IC50 of 850 nM. |
-
Cell Death Dis, 2019, 10(10):777
|
|
E4821New |
Simvastatin acid (ammonium)
|
Simvastatin acid (Tenivastatin) ammonium is a potent inhibitor of HMG-CoA reductase (HMGCR). Simvastatin acid ammonium also decreases Indoxyl sulfate-induced reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium regulates the expression of OATP3A1 in cardiomyocytes. |
|
|
E1341New |
Cerivastatin sodium
|
Cerivastatin sodium, a sodium salt of cerivastatin, is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase with Ki of 1.3 nM. It is also a synthetic, enantiomerically pure, pyridine derivative that effectively reduces serum cholesterol levels at microgram doses. |
|
|
E2286 |
Dihydrolanosterol
|
Dihydrolanosterol (24,25-Dihydrolanosterol; Dihydrolanosterin; Lanostenol) inhibits cholesterol biosynthesis by promoting ubiquitination and degradation of HMG CoA reductase. |
|
|
E2741New |
7-ketocholesterol
|
7-Ketocholesterol (7-Oxocholesterol), is a bioactive sterol and prominent cholesterol oxidation product, is a strong inhibitor of HMG-CoA reductase and cytochrome P450 7A1. It enhances oxidative stress, endoplasmic reticulum stress, and apoptosis in macrophages. |
|
|
S1792 |
Simvastatin
|
Simvastatin is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM in cell-free assays. Simvastatin induces ferroptosis, mitophagy, autophagy and apoptosis. |
- Cancer Med, 2024, 13(12):e7393
- Neuron, 2023, S0896-6273(23)00513-5
- Cancer Res, 2023, 83(13):2248-2261
|
|
S2061 |
Lovastatin
|
Lovastatin is an inhibitor of HMG-CoA reductase with IC50 of 3.4 nM in a cell-free assay, used for lowering cholesterol (hypolipidemic agent). Lovastatin triggers autophagy. |
- Cell Discov, 2024, 10(1):39
- Int J Biol Sci, 2024, 20(6):2130-2148
- Int J Biol Sci, 2024, 20(6):2130-2148
|
|
S1909 |
Fluvastatin Sodium
|
Fluvastatin Sodium inhibits HMG-CoA reductase activity with IC50 of 8 nM in a cell-free assay. |
- Oncogene, 2022, 41(39):4446-4458
- iScience, 2022, 25(10):105068
- BMC Cancer, 2022, 22(1):282
|
|
S5715 |
Atorvastatin
|
Atorvastatin is a lipid lowering agent. It is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway. Atorvastatin activates autophagy. |
- MedComm (2020), 2024, 5(5):e525
- Oncogene, 2024, 43(4):281-293
- Mol Cancer, 2023, 22(1):147
|
|
S1759 |
Pitavastatin calcium
|
Pitavastatin calcium, a novel member of the medication class of statins, is a calcium salt formulation of pitavastatin which is a highly effective HMG-CoA reductase inhibitor. Pitavastatin Calcium attenuates AGEs-induced mitophagy via inhibition of ROS generation. Pitavastatin Calcium induces autophagy and apoptosis. |
- Nat Commun, 2024, 15(1):4099
- Cell Rep, 2024, 43(6):114286
- bioRxiv, 2024, 2024.02.02.578510
|
|
S2169 |
Rosuvastatin calcium
|
Rosuvastatin calcium is a competitive inhibitor of HMG-CoA reductase with IC50 of 11 nM in a cell-free assay. |
- bioRxiv, 2024, 10.1101/2024.01.16.575899
- Neuron, 2023, S0896-6273(23)00513-5
- Int J Mol Sci, 2023, 24(9)8359
|
|
S2077 |
Atorvastatin Calcium
|
Atorvastatin Calcium is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol. Atorvastatin Calcium induces apoptosis and autophagy. |
- Cancers (Basel), 2022, 14(9)2327
- Nat Biotechnol, 2021, 10.1038/s41587-021-00860-4
- Neurobiol Dis, 2021, 152:105294
|
|
S3036 |
Pravastatin sodium
|
Pravastatin sodium (CS-514) is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM. |
- Int J Mol Sci, 2023, 24(7)6500
- J Cosmet Dermatol, 2022, 10.1111/jocd.15142
- Nat Biotechnol, 2021, 10.1038/s41587-021-00860-4
|
|
S4223 |
Mevastatin
|
Mevastatin (ML-236B,Compactin) is a competitive inhibitor of HMG-Coenzyme A (HMG-CoA) reductase with a binding affinity 10,000 times greater than the HMG-CoA substrate itself. |
- Nat Cardiovasc Res, 2023, 2(6):550-571
- Immunity, 2021, 54(10):2273-2287.e6
- Front Pharmacol, 2020, 11:574068
|
|
S5713 |
Pravastatin
|
Pravastatin(CS-514) is a lipoprotein-lowering drug via reversibly inhibiting hydroxymethylglutaryl-CoA (HMG-CoA) reductase and the synthesis of very-low-density lipoproteins. |
- EMBO Rep, 2022, e53373
- Biomedicines, 2022, 10(9)2123
- Front Cardiovasc Med, 2022, 9:921829
|
|
S2664 |
Clinofibrate
|
Clinofibrate inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR) with IC50 of 0.47 mM, is a lipid-lowering agent used for controlling high cholesterol and triacylglyceride levels in the blood. |
- Carcinogenesis, 2020, 7;bgaa036
|
|
S8302 |
SR-12813
|
SR-12813 is a pregnane X receptor (PXR) agonist and HMG-CoA reductase inhibitor with an IC50 of 850 nM. |
- Cell Death Dis, 2019, 10(10):777
|
|
E4821New |
Simvastatin acid (ammonium)
|
Simvastatin acid (Tenivastatin) ammonium is a potent inhibitor of HMG-CoA reductase (HMGCR). Simvastatin acid ammonium also decreases Indoxyl sulfate-induced reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium regulates the expression of OATP3A1 in cardiomyocytes. |
|
|
E1341New |
Cerivastatin sodium
|
Cerivastatin sodium, a sodium salt of cerivastatin, is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase with Ki of 1.3 nM. It is also a synthetic, enantiomerically pure, pyridine derivative that effectively reduces serum cholesterol levels at microgram doses. |
|
|
E2286 |
Dihydrolanosterol
|
Dihydrolanosterol (24,25-Dihydrolanosterol; Dihydrolanosterin; Lanostenol) inhibits cholesterol biosynthesis by promoting ubiquitination and degradation of HMG CoA reductase. |
|
|
E2741New |
7-ketocholesterol
|
7-Ketocholesterol (7-Oxocholesterol), is a bioactive sterol and prominent cholesterol oxidation product, is a strong inhibitor of HMG-CoA reductase and cytochrome P450 7A1. It enhances oxidative stress, endoplasmic reticulum stress, and apoptosis in macrophages. |
|
|