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HMG-CoA Reductase

HMG-CoA Reductase Products

All (17)
HMG-CoA Reductase Inhibitors (17)
New HMG-CoA Reductase Products

Catalog No.	Product Name	Information	Product Use Citations
S1792	Simvastatin	Simvastatin is a competitive inhibitor of HMG-CoA reductase with K_i of 0.1-0.2 nM in cell-free assays. Simvastatin induces ferroptosis, mitophagy, autophagy and apoptosis.	J Immunother Cancer, 2024, 12(11)e009805 Cancer Med, 2024, 13(12):e7393 Neuron, 2023, S0896-6273(23)00513-5
S2061	Lovastatin	Lovastatin is an inhibitor of HMG-CoA reductase with IC50 of 3.4 nM in a cell-free assay, used for lowering cholesterol (hypolipidemic agent). Lovastatin triggers autophagy.	Cell Discov, 2024, 10(1):39 Nat Commun, 2024, 15(1):6740 Int J Biol Sci, 2024, 20(6):2130-2148
S1909	Fluvastatin Sodium	Fluvastatin Sodium inhibits HMG-CoA reductase activity with IC50 of 8 nM in a cell-free assay.	J Immunother Cancer, 2024, 12(11)e009805 Oncogene, 2022, 41(39):4446-4458 iScience, 2022, 25(10):105068
S5715	Atorvastatin	Atorvastatin is a lipid lowering agent. It is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway. Atorvastatin activates autophagy.	MedComm (2020), 2024, 5(5):e525 Oncogene, 2024, 43(4):281-293 Mol Cancer, 2023, 22(1):147
S1759	Pitavastatin calcium	Pitavastatin calcium, a novel member of the medication class of statins, is a calcium salt formulation of pitavastatin which is a highly effective HMG-CoA reductase inhibitor. Pitavastatin Calcium attenuates AGEs-induced mitophagy via inhibition of ROS generation. Pitavastatin Calcium induces autophagy and apoptosis.	Nat Commun, 2024, 15(1):4099 J Immunother Cancer, 2024, 12(11)e009805 Cell Rep, 2024, 43(6):114286
S2169	Rosuvastatin calcium	Rosuvastatin calcium is a competitive inhibitor of HMG-CoA reductase with IC50 of 11 nM in a cell-free assay.	J Immunother Cancer, 2024, 12(11)e009805 bioRxiv, 2024, 10.1101/2024.01.16.575899 Neuron, 2023, S0896-6273(23)00513-5
S2077	Atorvastatin Calcium	Atorvastatin Calcium is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol. Atorvastatin Calcium induces apoptosis and autophagy.	J Immunother Cancer, 2024, 12(11)e009805 Cancers (Basel), 2022, 14(9)2327 Nat Biotechnol, 2021, 10.1038/s41587-021-00860-4
S3036	Pravastatin sodium	Pravastatin sodium (CS-514) is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.	Int J Mol Sci, 2023, 24(7)6500 J Cosmet Dermatol, 2022, 10.1111/jocd.15142 Nat Biotechnol, 2021, 10.1038/s41587-021-00860-4
S4223	Mevastatin	Mevastatin (ML-236B,Compactin) is a competitive inhibitor of HMG-Coenzyme A (HMG-CoA) reductase with a binding affinity 10,000 times greater than the HMG-CoA substrate itself.	J Immunother Cancer, 2024, 12(11)e009805 Nat Cardiovasc Res, 2023, 2(6):550-571 Immunity, 2021, 54(10):2273-2287.e6
S5713	Pravastatin	Pravastatin(CS-514) is a lipoprotein-lowering drug via reversibly inhibiting hydroxymethylglutaryl-CoA (HMG-CoA) reductase and the synthesis of very-low-density lipoproteins.	EMBO Rep, 2022, e53373 Biomedicines, 2022, 10(9)2123 Front Cardiovasc Med, 2022, 9:921829
S2664	Clinofibrate	Clinofibrate inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR) with IC50 of 0.47 mM, is a lipid-lowering agent used for controlling high cholesterol and triacylglyceride levels in the blood.	Carcinogenesis, 2020, 7;bgaa036
S8302	SR-12813	SR-12813 is a pregnane X receptor (PXR) agonist and HMG-CoA reductase inhibitor with an IC50 of 850 nM.	Evid Based Complement Alternat Med, 2021, 2021:4358163 Cell Death Dis, 2019, 10(10):777
E4821^New	Simvastatin acid (ammonium)	Simvastatin acid (Tenivastatin) ammonium is a potent inhibitor of HMG-CoA reductase (HMGCR). Simvastatin acid ammonium also decreases Indoxyl sulfate-induced reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium regulates the expression of OATP3A1 in cardiomyocytes.
E1341^New	Cerivastatin sodium	Cerivastatin sodium, a sodium salt of cerivastatin, is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase with Ki of 1.3 nM. It is also a synthetic, enantiomerically pure, pyridine derivative that effectively reduces serum cholesterol levels at microgram doses.
E4792^New	Atorvastatin calcium hydrate	Atorvastatin calcium hydrate (Totalip) is a potent inhibitor of the HMG-CoA reductase . It is used as a potent hypolipidemic agent to reduce the elevated total-cholesterol, low-density lipoprotein (LDL), apolipoprotein B (apo B), and triglyceride (TG) levels, and to increase the high-density lipoprotein cholesterol (HDL-C) level in patients with primary hypercholesterolemia and mixed dyslipidemia.
E2286	Dihydrolanosterol	Dihydrolanosterol (24,25-Dihydrolanosterol; Dihydrolanosterin; Lanostenol) inhibits cholesterol biosynthesis by promoting ubiquitination and degradation of HMG CoA reductase.
E2741^New	7-ketocholesterol	7-Ketocholesterol (7-Oxocholesterol), is a bioactive sterol and prominent cholesterol oxidation product, is a strong inhibitor of HMG-CoA reductase and cytochrome P450 7A1. It enhances oxidative stress, endoplasmic reticulum stress, and apoptosis in macrophages.
S1792	Simvastatin	Simvastatin is a competitive inhibitor of HMG-CoA reductase with K_i of 0.1-0.2 nM in cell-free assays. Simvastatin induces ferroptosis, mitophagy, autophagy and apoptosis.	J Immunother Cancer, 2024, 12(11)e009805 Cancer Med, 2024, 13(12):e7393 Neuron, 2023, S0896-6273(23)00513-5
S2061	Lovastatin	Lovastatin is an inhibitor of HMG-CoA reductase with IC50 of 3.4 nM in a cell-free assay, used for lowering cholesterol (hypolipidemic agent). Lovastatin triggers autophagy.	Cell Discov, 2024, 10(1):39 Nat Commun, 2024, 15(1):6740 Int J Biol Sci, 2024, 20(6):2130-2148
S1909	Fluvastatin Sodium	Fluvastatin Sodium inhibits HMG-CoA reductase activity with IC50 of 8 nM in a cell-free assay.	J Immunother Cancer, 2024, 12(11)e009805 Oncogene, 2022, 41(39):4446-4458 iScience, 2022, 25(10):105068
S5715	Atorvastatin	Atorvastatin is a lipid lowering agent. It is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway. Atorvastatin activates autophagy.	MedComm (2020), 2024, 5(5):e525 Oncogene, 2024, 43(4):281-293 Mol Cancer, 2023, 22(1):147
S1759	Pitavastatin calcium	Pitavastatin calcium, a novel member of the medication class of statins, is a calcium salt formulation of pitavastatin which is a highly effective HMG-CoA reductase inhibitor. Pitavastatin Calcium attenuates AGEs-induced mitophagy via inhibition of ROS generation. Pitavastatin Calcium induces autophagy and apoptosis.	Nat Commun, 2024, 15(1):4099 J Immunother Cancer, 2024, 12(11)e009805 Cell Rep, 2024, 43(6):114286
S2169	Rosuvastatin calcium	Rosuvastatin calcium is a competitive inhibitor of HMG-CoA reductase with IC50 of 11 nM in a cell-free assay.	J Immunother Cancer, 2024, 12(11)e009805 bioRxiv, 2024, 10.1101/2024.01.16.575899 Neuron, 2023, S0896-6273(23)00513-5
S2077	Atorvastatin Calcium	Atorvastatin Calcium is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol. Atorvastatin Calcium induces apoptosis and autophagy.	J Immunother Cancer, 2024, 12(11)e009805 Cancers (Basel), 2022, 14(9)2327 Nat Biotechnol, 2021, 10.1038/s41587-021-00860-4
S3036	Pravastatin sodium	Pravastatin sodium (CS-514) is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.	Int J Mol Sci, 2023, 24(7)6500 J Cosmet Dermatol, 2022, 10.1111/jocd.15142 Nat Biotechnol, 2021, 10.1038/s41587-021-00860-4
S4223	Mevastatin	Mevastatin (ML-236B,Compactin) is a competitive inhibitor of HMG-Coenzyme A (HMG-CoA) reductase with a binding affinity 10,000 times greater than the HMG-CoA substrate itself.	J Immunother Cancer, 2024, 12(11)e009805 Nat Cardiovasc Res, 2023, 2(6):550-571 Immunity, 2021, 54(10):2273-2287.e6
S5713	Pravastatin	Pravastatin(CS-514) is a lipoprotein-lowering drug via reversibly inhibiting hydroxymethylglutaryl-CoA (HMG-CoA) reductase and the synthesis of very-low-density lipoproteins.	EMBO Rep, 2022, e53373 Biomedicines, 2022, 10(9)2123 Front Cardiovasc Med, 2022, 9:921829
S2664	Clinofibrate	Clinofibrate inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR) with IC50 of 0.47 mM, is a lipid-lowering agent used for controlling high cholesterol and triacylglyceride levels in the blood.	Carcinogenesis, 2020, 7;bgaa036
S8302	SR-12813	SR-12813 is a pregnane X receptor (PXR) agonist and HMG-CoA reductase inhibitor with an IC50 of 850 nM.	Evid Based Complement Alternat Med, 2021, 2021:4358163 Cell Death Dis, 2019, 10(10):777
E4821^New	Simvastatin acid (ammonium)	Simvastatin acid (Tenivastatin) ammonium is a potent inhibitor of HMG-CoA reductase (HMGCR). Simvastatin acid ammonium also decreases Indoxyl sulfate-induced reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium regulates the expression of OATP3A1 in cardiomyocytes.
E1341^New	Cerivastatin sodium	Cerivastatin sodium, a sodium salt of cerivastatin, is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase with Ki of 1.3 nM. It is also a synthetic, enantiomerically pure, pyridine derivative that effectively reduces serum cholesterol levels at microgram doses.
E4792^New	Atorvastatin calcium hydrate	Atorvastatin calcium hydrate (Totalip) is a potent inhibitor of the HMG-CoA reductase . It is used as a potent hypolipidemic agent to reduce the elevated total-cholesterol, low-density lipoprotein (LDL), apolipoprotein B (apo B), and triglyceride (TG) levels, and to increase the high-density lipoprotein cholesterol (HDL-C) level in patients with primary hypercholesterolemia and mixed dyslipidemia.
E2286	Dihydrolanosterol	Dihydrolanosterol (24,25-Dihydrolanosterol; Dihydrolanosterin; Lanostenol) inhibits cholesterol biosynthesis by promoting ubiquitination and degradation of HMG CoA reductase.
E2741^New	7-ketocholesterol	7-Ketocholesterol (7-Oxocholesterol), is a bioactive sterol and prominent cholesterol oxidation product, is a strong inhibitor of HMG-CoA reductase and cytochrome P450 7A1. It enhances oxidative stress, endoplasmic reticulum stress, and apoptosis in macrophages.
E4821^New	Simvastatin acid (ammonium)	Simvastatin acid (Tenivastatin) ammonium is a potent inhibitor of HMG-CoA reductase (HMGCR). Simvastatin acid ammonium also decreases Indoxyl sulfate-induced reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium regulates the expression of OATP3A1 in cardiomyocytes.
E1341^New	Cerivastatin sodium	Cerivastatin sodium, a sodium salt of cerivastatin, is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase with Ki of 1.3 nM. It is also a synthetic, enantiomerically pure, pyridine derivative that effectively reduces serum cholesterol levels at microgram doses.
E4792^New	Atorvastatin calcium hydrate	Atorvastatin calcium hydrate (Totalip) is a potent inhibitor of the HMG-CoA reductase . It is used as a potent hypolipidemic agent to reduce the elevated total-cholesterol, low-density lipoprotein (LDL), apolipoprotein B (apo B), and triglyceride (TG) levels, and to increase the high-density lipoprotein cholesterol (HDL-C) level in patients with primary hypercholesterolemia and mixed dyslipidemia.
E2741^New	7-ketocholesterol	7-Ketocholesterol (7-Oxocholesterol), is a bioactive sterol and prominent cholesterol oxidation product, is a strong inhibitor of HMG-CoA reductase and cytochrome P450 7A1. It enhances oxidative stress, endoplasmic reticulum stress, and apoptosis in macrophages.

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