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Formula | C30H41FN4O12 |
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Molecular Weight | 668.66 | CAS No. | 210344-95-9 | |
Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (149.55 mM) | |
Water | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | Z-DEVD-FMK (Caspase-3 Inhibitor) is a specific, irreversible Caspase-3 inhibitor, and also shows potent inhibition on caspase-6, caspase-7, caspase-8, and caspase-10. | |
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Targets |
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In vitro | Z-DEVD-FMK (1–200 μM) inhibits D4-GDI cleavage and apoptosis in a concentration-dependent manner. [1] Z-DEVD-FMK reduces ceramide-induced cardiomyocyte death and significantly inhibits the activation of caspase 3. [3] Z-DEVD-FMK (100μM) attenuates OxyHb-induced cell detachment, reduced caspase-2 and -3 activities, abolishes OxyHb-induced DNA ladders, and prevents OxyHb-induced cleavage of PARP in cultured brain microvessel endothelial cells. [4] Z-DEVD-FMK (100 μM) blocks MPP+-induced increases in caspase-3 enzyme activity. Z-DEVD-FMK dose dependently blocks 6-OHDA-induced apoptotic cell death with IC50 of 18 μM. [5] | |
In vivo | Z-DEVD-FMK, before and after injury, markedly reduces post-traumatic apoptosis, and significantly improved neurological recovery. [2] |
Kinase Assay:[5] |
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Cell Assay:[5] |
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Animal Study:[2] |
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, , Mol Carcinog, 2016, 56(1):218-231
Data from [Data independently produced by , , Oncotarget, 2017, 8(2):3396-3411]
Data from [Data independently produced by , , INTERNATIONAL JOURNAL OF ONCOLOGY, 2016, 48:1710-1720.]
Pyroptotic T cell-derived active IL-16 has a driving function in ovarian endometriosis development [ Cell Rep Med, 2024, 5(3):101476] | PubMed: 38508138 |
PARP inhibitors enhance antitumor immune responses by triggering pyroptosis via TNF-caspase 8-GSDMD/E axis in ovarian cancer [ J Immunother Cancer, 2024, 12(10)e009032] | PubMed: 39366751 |
Induction of IFIT1/IFIT3 and inhibition of Bcl-2 orchestrate the treatment of myeloma and leukemia via pyroptosis [ Cancer Lett, 2024, 588:216797] | PubMed: 38462032 |
Receptor-interacting protein kinase 1 confers autophagic promotion of gasdermin E-mediated pyroptosis in aristolochic acid-induced acute kidney injury [ Ecotoxicol Environ Saf, 2024, 284:116944] | PubMed: 39208575 |
Pseudorabies virus gM and its homologous proteins in herpesviruses induce mitochondria-related apoptosis involved in viral pathogenicity [ PLoS Pathog, 2024, 20(4):e1012146] | PubMed: 38669242 |
Haemolysins are essential to the pathogenicity of deep-sea Vibrio fluvialis [ iScience, 2024, 27(5):109558] | PubMed: 38650982 |
Chemical Hypoxia Induces Pyroptosis in Neuronal Cells by Caspase-Dependent Gasdermin Activation [ Int J Mol Sci, 2024, 25(4)2185] | PubMed: 38396860 |
African swine fever virus infection regulates pyroptosis by cleaving gasdermin A (GSDMA) via active caspase-3 and caspase-4 [ J Biol Chem, 2024, S0021-9258(24)01808-8] | PubMed: 38657868 |
G9a-targeted chaetocin induces pyroptosis of gastric cancer cells [ Asian Pac J Trop Bio, 2023;, 13(6): 268-276] | PubMed: none |
Carboxypeptidase A4 negatively regulates HGS-ETR1/2-induced pyroptosis by forming a positive feedback loop with the AKT signalling pathway [ Cell Death Dis, 2023, 14(12):793] | PubMed: 38049405 |
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.