Toll Free: (877) 796-6397 -- USA and Canada only -- |
Fax: +1-832-582-8590 Orders: +1-832-582-8158 |
Tech Support: +1-832-582-8158 Ext:3 Please provide your Order Number in the email. |
Formula | C26H27F4N3O7 |
|||
Molecular Weight | 569.50 | CAS No. | 254750-02-2 | |
Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (175.59 mM) | |
Ethanol | 25 mg/mL (43.89 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | Emricasan (IDN-6556, PF 03491390, PF-03491390) is a potent irreversible pan-caspase inhibitor. Emricasan is an inhibitor of Zika virus infection. | |
---|---|---|
Targets |
|
|
In vitro | Emricasan, also called IDN-6556 or PF-03491390, is an inhibitor of activated caspases, and it has sub- to nanomolar activity in vitro. Emricasan shows neuroprotective activity for hNPCs but does not suppress ZIKV replication[2]. | |
In vivo | Emricasan decreases liver injury but not metabolic derangement in NASH. It also ameliorates inflammation. In the murine NASH model, stellate cell activation and hepatic fibrogenesis are attenuated by administration of the pan-caspase inhibitor Emricasan[1]. Emricasan is currently being evaluated in phase 2 clinical trials for the reduction of hepatic injury and liver fibrosis caused by chronic HCV infection[2]. |
Cell Assay:[2] |
|
---|---|
Animal Study:[1] |
|
|
The RIPK1 death domain restrains ZBP1- and TRIF-mediated cell death and inflammation [ Immunity, 2024, S1074-7613(24)00221-8] | PubMed: 38744293 |
Neuronal STING activation in amyotrophic lateral sclerosis and frontotemporal dementia [ Acta Neuropathol, 2024, 147(1):56] | PubMed: 38478117 |
ZBP1 causes inflammation by inducing RIPK3-mediated necroptosis and RIPK1 kinase activity-independent apoptosis [ Cell Death Differ, 2024, 31(7):938-953] | PubMed: 38849574 |
Caspase cleavage of RIPK3 after Asp333 is dispensable for mouse embryogenesis [ Cell Death Differ, 2024, 31(2):254-262.] | PubMed: 38191748 |
Hepatocyte-macrophage crosstalk via the PGRN-EGFR axis modulates ADAR1-mediated immunity in the liver [ Cell Rep, 2024, 43(7):114400] | PubMed: 38935501 |
Craniofacial chondrogenesis in organoids from human stem cell-derived neural crest cells [ iScience, 2024, 27(4):109585] | PubMed: 38623327 |
Anti-apoptotic treatment of warm ischemic male rat livers in machine perfusion improves symptoms of ischemia-reperfusion injury [ Heliyon, 2024, 10(8):e29519] | PubMed: 38660283 |
Regenerative human liver organoids (HLOs) in a pillar/perfusion plate for hepatotoxicity assays [ bioRxiv, 2024, 2024.03.25.586638] | PubMed: 38586058 |
Reproducible generation of human liver organoids (HLOs) on a pillar plate platform via microarray 3D bioprinting [ bioRxiv, 2024, 2024.03.11.584478] | PubMed: 38559126 |
Synaptic plasticity in human thalamocortical assembloids [ bioRxiv, 2024, 2024.02.01.578421] | PubMed: 38352415 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.