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Formula | C62H111N11O12 |
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Molecular Weight | 1202.61 | CAS No. | 59865-13-3 | ||||
Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (83.15 mM) | ||||
Ethanol | 100 mg/mL (83.15 mM) | ||||||
Water | Insoluble | ||||||
In vivo (Add solvents to the product individually and in order) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | Cyclosporin A, a non-polar cyclic oligopeptide, is an immunosuppressive agent that binds to cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay. Cyclosporin A is generally given following transplant surgery to prevent rejection and has been used to test its toxic effect on a perfused 3D proximal tubule model. | ||
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Targets |
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In vitro | Cyclosporin A binds to the cyclophilin (immunophilin) in T cells[1] , forms a Cyclophilin-Cyclosporin A complex which the binds to and inhibits calcineurin. [2] Cyclosporin A inhibits calcineurin with IC50 of 7 nM[3], then blocks the nuclear translocation of NF-AT. [4] Cyclosporin A also affects mitochondria by preventing the MTP (mitochondrial permeability transition pore) from opening with an IC50 of 39 nM. [5] |
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In vivo | Cyclosporin A is an immunosuppressive agent that is effective following either parenteral or oral administration in mice, rat and guinea pigs. [6], is clinically used in organ transplantation to prevent rejection. [7] |
Kinase Assay: |
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Data from [Biochim Biophys Acta, 2013, 1833(3), 652-62]
Data from [Biochim Biophys Acta, 2013, 1833(3), 652-62]
Data from [Data independently produced by , , Pharm Res, 2016, 33(2):395-403]
LKB1 prevents ILC2 exhaustion to enhance antitumor immunity [ Cell Rep, 2024, S2211-1247(23)01591-7] | PubMed: 38670109 |
Calcineurin-dependent contributions to fitness in the opportunistic pathogen Candida glabrata [ mSphere, 2024, 9(1):e0055423] | PubMed: 38171022 |
Amanitin-induced variable cytotoxicity in various cell lines is mediated by the different expression levels of OATP1B3 [ Food Chem Toxicol, 2024, 188:114665] | PubMed: 38641045 |
Select EZH2 inhibitors enhance viral mimicry effects of DNMT inhibition through a mechanism involving NFAT:AP-1 signaling [ Sci Adv, 2024, 10(13):eadk4423] | PubMed: 38536911 |
The cGAS-STING pathway-dependent sensing of mitochondrial DNA mediates ocular surface inflammation [ Signal Transduct Target Ther, 2023, 8(1):371] | PubMed: 37735446 |
The cGAS-STING pathway-dependent sensing of mitochondrial DNA mediates ocular surface inflammation [ Signal Transduct Target Ther, 2023, 8(1):371] | PubMed: 37735446 |
Three-dimensional nanofibrous sponges with aligned architecture and controlled hierarchy regulate neural stem cell fate for spinal cord regeneration [ Theranostics, 2023, 10.7150/thno.87288] | PubMed: 37771775 |
VMP1 affects endoplasmic reticulum stress sensitivity via differential modulation of the three unfolded protein response arms [ Cell Rep, 2023, 42(3):112209] | PubMed: 36870060 |
A novel implant surface modification mode of Fe3O4-containing TiO2 nanorods with sinusoidal electromagnetic field for osteoblastogenesis and angiogenesis [ Mater Today Bio, 2023, 19:100590] | PubMed: 36910272 |
IP3R-dependent mitochondrial dysfunction mediates C5b-9-induced ferroptosis in trichloroethylene-caused immune kidney injury [ Front Immunol, 2023, 14:1106693] | PubMed: 37383224 |
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