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Gamma-secretase

Gamma-secretase Products

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Catalog No. Product Name Information Product Use Citations Product Validations
S8185 FPS-ZM1 FPS-ZM1 is a blood-brain-barrier permeant, non-toxic, tertiary amide compound which is a high affinity RAGE-specific inhibitor, blocking Aβ binding to the V domain of RAGE.
Clin Immunol, 2024, 262:110178
Pharmacol Res, 2023, 192:106791
Cell Death Dis, 2023, 14(12):825
S7169 Crenigacestat (LY3039478) Crenigacestat (LY3039478) is an oral Notch and gamma-secretase inhibitor with IC50 of 0.41 nM for Notch.
J Exp Clin Cancer Res, 2024, 43(1):286
Cell Death Dis, 2024, 15(1):53
MedComm (2020), 2023, 4(5):e346
S8185 FPS-ZM1 FPS-ZM1 is a blood-brain-barrier permeant, non-toxic, tertiary amide compound which is a high affinity RAGE-specific inhibitor, blocking Aβ binding to the V domain of RAGE.
Clin Immunol, 2024, 262:110178
Pharmacol Res, 2023, 192:106791
Cell Death Dis, 2023, 14(12):825
S7169 Crenigacestat (LY3039478) Crenigacestat (LY3039478) is an oral Notch and gamma-secretase inhibitor with IC50 of 0.41 nM for Notch.
J Exp Clin Cancer Res, 2024, 43(1):286
Cell Death Dis, 2024, 15(1):53
MedComm (2020), 2023, 4(5):e346

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Tags: Gamma-secretase inhibition | Gamma-secretase inhibitor Notch | Gamma-secretase activity | Gamma-secretase assay | Gamma-secretase cleavage | Gamma-secretase inhibitor in clinical trial | Gamma-secretase inhibitor review