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VDA Products

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Catalog No. Product Name Information Product Use Citations Product Validations
S1786 Verteporfin Verteporfin is a small molecule that inhibits TEAD–YAP association and YAP-induced liver overgrowth. It is also a potent second-generation photosensitizing agent derived from porphyrin. Verteporfin is an autophagy inhibitor. Verteporfin inhibits cell proliferation and induces apoptosis.
Cell Death Differ, 2025, 10.1038/s41418-025-01446-2
Biochem Pharmacol, 2025, 231:116641
Front Pharmacol, 2025, 16:1496511
S1537 Vadimezan (DMXAA) Vadimezan (DMXAA) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM in cell-free assays, respectively. DMXAA (Vadimezan) is also a STING agonist with potential antineoplastic activity. DMXAA (Vadimezan) potently induces IFN-β but relatively low TNF-α expression in vitro. DMXAA (Vadimezan) has antiviral activity. Phase 3.
Cell Chem Biol, 2025, 32(2):280-290.e14
Front Pharmacol, 2025, 16:1528459
Immun Inflamm Dis, 2025, 13(1):e70139
S1176 Plinabulin Plinabulin is a vascular disrupting agent (VDA) against tubulin-depolymerizing with IC50 of 9.8~18 nM in tumor cells. Phase 1/2.
J Med Chem, 2022, 65(13):9159-9173
ACS Omega, 2022, 7(25):21465-21472
J Biol Chem, 2019, 294(20):8161-8170

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