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TOPK

TOPK Products

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Catalog No. Product Name Information Product Use Citations Product Validations
S7652 OTS514 hydrochloride OTS514 is a highly potent TOPK(T-LAK cell-originated protein kinase) inhibitor with an IC50 value of 2.6 nM. OTS514 induces cell cycle arrest and apoptosis.
Exp Mol Med, 2022, 54(7):999-1010
Mol Oncol, 2021, 15(12):3721-3737
Oncogenesis, 2021, 10(1):9
S7648 OTS964 OTS964 is a potent TOPK inhibitor with high affinity and selectivity and IC50 value is 28 nM. OTS964 is also a potent inhibitor of the cyclin-dependent kinase CDK11 with Kd of 40 nM. OTS964 treatment activates autophagy in glioma cells and induces apoptosis of human lung cancer cells in mouse xenografts.
Sci Adv, 2025, 11(4):eadq2395
Nucleic Acids Res, 2023, gkad001
Graduate Department of Biochemistry University of Toronto, 2023,
S6882 HI-TOPK-032 HI-TOPK-032 is a potent and specific inhibitor of TOPK. HI-TOPK-032 also reduces ERK-RSK phosphorylation, regulates of the abundance of p53, cleaved caspase-7, and cleaved PARP, and induces apoptosis in cancer cells.
S7652 OTS514 hydrochloride OTS514 is a highly potent TOPK(T-LAK cell-originated protein kinase) inhibitor with an IC50 value of 2.6 nM. OTS514 induces cell cycle arrest and apoptosis.
Exp Mol Med, 2022, 54(7):999-1010
Mol Oncol, 2021, 15(12):3721-3737
Oncogenesis, 2021, 10(1):9
S7648 OTS964 OTS964 is a potent TOPK inhibitor with high affinity and selectivity and IC50 value is 28 nM. OTS964 is also a potent inhibitor of the cyclin-dependent kinase CDK11 with Kd of 40 nM. OTS964 treatment activates autophagy in glioma cells and induces apoptosis of human lung cancer cells in mouse xenografts.
Sci Adv, 2025, 11(4):eadq2395
Nucleic Acids Res, 2023, gkad001
Graduate Department of Biochemistry University of Toronto, 2023,
S6882 HI-TOPK-032 HI-TOPK-032 is a potent and specific inhibitor of TOPK. HI-TOPK-032 also reduces ERK-RSK phosphorylation, regulates of the abundance of p53, cleaved caspase-7, and cleaved PARP, and induces apoptosis in cancer cells.

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Tags: TOPK Inhibition | TOPK Inhibitor | TOPK activity | TOPK activation | TOPK phosphorylation