MTH1 inhibition | MTH1 inhibitor review

Catalog No.	Product Name	Information	Product Use Citations
S7505	(S)-crizotinib	(S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM in a cell-free assay.	Bio Protoc, 2023, 10.21769/BioProtoc.4870 Am J Respir Crit Care Med, 2020, 10.1164/rccm.202003-0627OC Antiviral Res, 2020, 178:104790
S7632	TH588	TH588 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 5 nM. It has no relevant inhibition of any of the other tested proteins at 100 μM, although TH588 showed reasonable selectivity when tested on a much larger panel of 87 enzymes, GPCRs, kinases, ion channels and transporters at 10 μM.	Adv Healthc Mater, 2024, e2402349. Colloids Surf B Biointerfaces, 2022, 218:112715 Cell Syst, 2019, 9(1):74-92.e8
S7631	TH287	TH287 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 0.8 nM.	Nat Commun, 2024, 15(1):2377 Breast Cancer Res, 2022, 24(1):41 Oncogene, 2021, 10.1038/s41388-021-02105-9
S7505	(S)-crizotinib	(S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM in a cell-free assay.	Bio Protoc, 2023, 10.21769/BioProtoc.4870 Am J Respir Crit Care Med, 2020, 10.1164/rccm.202003-0627OC Antiviral Res, 2020, 178:104790
S7632	TH588	TH588 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 5 nM. It has no relevant inhibition of any of the other tested proteins at 100 μM, although TH588 showed reasonable selectivity when tested on a much larger panel of 87 enzymes, GPCRs, kinases, ion channels and transporters at 10 μM.	Adv Healthc Mater, 2024, e2402349. Colloids Surf B Biointerfaces, 2022, 218:112715 Cell Syst, 2019, 9(1):74-92.e8
S7631	TH287	TH287 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 0.8 nM.	Nat Commun, 2024, 15(1):2377 Breast Cancer Res, 2022, 24(1):41 Oncogene, 2021, 10.1038/s41388-021-02105-9

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