Home Transmembrane Transporters Calcium Channel agonist Cinacalcet For research use only.

Cinacalcet

Synonyms: AMG073, Sensipar, Cin

Cinacalcet (AMG073, Sensipar, Cin) is an orally active, allosteric agonist of receptors for calcium (CaR) that increases the sensitivity of the CaR to Ca.

Cinacalcet Chemical Structure

Cinacalcet Chemical Structure

CAS No. 226256-56-0

Purity & Quality Control

Cinacalcet Related Products

Signaling Pathway

Calcium Channel Signaling Pathways

Calcium Channel Signaling Pathway

Biological Activity

Description Cinacalcet (AMG073, Sensipar, Cin) is an orally active, allosteric agonist of receptors for calcium (CaR) that increases the sensitivity of the CaR to Ca.
Targets
CaR [1]
In vitro
In vitro

Cinacalcet can activate CaSR and elicit an increase of atg7, becn and lc3a mRNA transcripts.[2]
Cell Research Cell lines human AT-derived (primary) preadipocytes
Concentrations 2 μM
Incubation Time 6 h
Method

Isolation of human AT-derived (primary) preadipocytes was performed. After passage 3 in culture with DMEM:F12 and 10% FBS, preadipocytes were switched to 2.5% FBS and exposed to cinacalcet, spermine and/or the upstream ERK (MAPK) inhibitor U0126, plus the autophagy flux inhibitor CQ for the last 2-3 h. CaSR activators were used for 6 h, while U0126 was used 1 h before exposure to the CaSR activator.

(Data sourced from selleck products)
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06403618 Not yet recruiting
Cervical Intraepithelial Neoplasia Grade 2
European Institute of Oncology
 May 15 2024 --
NCT06210854 Not yet recruiting
HPV Infection
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
 May 2024 Phase 2
NCT06213051 Not yet recruiting
Human Papillomavirus Infection
Foundation for Innovative New Diagnostics Switzerland|Kenya Medical Research Institute|Frere Hospital East London South Africa
 April 1 2024 --

Chemical Information & Solubility

Molecular Weight 357.41 Formula

C22H22F3N
CAS No. 226256-56-0 SDF --
Smiles CC(NCCCC1=CC(=CC=C1)C(F)(F)F)C2=CC=CC3=CC=CC=C23
Storage (From the date of receipt) 2 years -20°C liquid

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