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Iptacopan (LNP023) Hydrochloride

Name: Iptacopan (LNP023) Hydrochloride
Brand: Selleck Chemicals
SKU: E0119
Rating: 5 (1 reviews)

Synonyms: LNP023 HCl

Catalog No.E0119 Purity:99.97%

Iptacopan (LNP023) Hydrochloride is a first-in-class, orally administered, potent and highly selective factor B inhibitor with an IC50 of 12 nM and a Kd value of 7.9 nM. Iptacopan exhibits excellent selectivity over other proteases affording IC50s of >30 μM across a panel of 41 human proteases.

Iptacopan (LNP023) Hydrochloride Chemical Structure

CAS No. 1646321-63-2

Purity & Quality Control

Batch: E011901 DMSO]85 mg/mL]false]Ethanol]85 mg/mL]false]Water]5 mg/mL]false Purity: 99.97%

99.97

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Biological Activity

Description

Targets

factor B ^[1]

12 nM

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT05630001	Recruiting	Paroxysmal Nocturnal Hemoglobinuria	Novartis Pharmaceuticals\|Novartis	April 24 2023	Phase 3
NCT05230537	Recruiting	Age-Related Macular Degeneration	Novartis Pharmaceuticals\|Novartis	February 17 2022	Phase 2
NCT05078580	Completed	Hepatic Impairment	Novartis Pharmaceuticals\|Novartis	November 10 2021	Phase 1
NCT04558918	Completed	Paroxysmal Nocturnal Hemoglobinuria (PNH)	Novartis Pharmaceuticals\|Novartis	January 25 2021	Phase 3
NCT03955445	Recruiting	C3 Glomerulopathy	Novartis Pharmaceuticals\|Novartis	October 3 2019	Phase 3
NCT03832114	Completed	Glomerulonephritis	Novartis Pharmaceuticals\|Novartis	February 20 2019	Phase 2

References

[1] Nello Mainolfi, et al. J Med Chem. 2020 Jun 11;63(11):5697-5722.

Chemical Information & Solubility

Molecular Weight	458.98	Formula	C₂₅H₃₁ClN₂O₄
CAS No.	1646321-63-2	SDF	--
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 85 mg/mL ( (185.19 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 85 mg/mL

Water : 5 mg/mL

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
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