Home Metabolism Hydroxylase activator Isotretinoin (13-cis retinoic acid) For research use only.

Isotretinoin (13-cis retinoic acid)

Isotretinoin (13-cis retinoic acid) was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.

Isotretinoin (13-cis retinoic acid) Chemical Structure

Isotretinoin (13-cis retinoic acid) Chemical Structure

CAS No. 4759-48-2

Purity & Quality Control

Isotretinoin (13-cis retinoic acid) Related Products

Signaling Pathway

Hydroxylase Signaling Pathways

Hydroxylase Signaling Pathway

Biological Activity

Description Isotretinoin (13-cis retinoic acid) was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.
Targets
hydroxylase [1]
In vitro
In vitro Isotretinoin directly interferes with the development of cranial neural crest cells. [1] Isotretinoin selectively affects neural crest cells by decreasing their cell-substratum adhesion. [2]
In Vivo
In vivo Isotretinoin (500 ng/mL) and its main metabolite in the human, 4-oxo-isotretinoin, induce malformations similar to those seen in vivo. [1] Isotretinoin impairs explicit memory in Stage 2, but retention tests one month after Isotretinoin exposure ended, indicated recovery from this explicit memory impairment and evidence of enhanced implicit memory in the 10 mg and 15 mg ISO rats. [3] Isotretinoin slows the recovery of rod signaling after exposure to an intense bleaching light, and that rhodopsin regeneration is markedly slowed. Isotretinoin is also found to protect rat photoreceptors from light-induced damage. [4] Isotretinoin blocks the formation of A2E biochemically and the accumulation of lipofuscin pigments by electron microscopy. Isotretinoin also blocks the slower, age-dependent accumulation of lipofuscin in wild-type mice. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06225570 Not yet recruiting
Acne Vulgaris
Medical University of South Carolina
 January 2025 Early Phase 1
NCT05316675 Not yet recruiting
Acne Vulgaris
Assiut University
 December 2022 Phase 4
NCT03939364 Withdrawn
Leukoplakia Oral
Skyline Biosciences
 January 2022 Phase 1
NCT05218486 Active not recruiting
Acne Vulgaris
Alshimaa Abbas Mohamed Ebrahim|Aswan University
 August 1 2021 Phase 4

Chemical Information & Solubility

Molecular Weight 300.44 Formula

C20H28O2
CAS No. 4759-48-2 SDF Download Isotretinoin (13-cis retinoic acid) SDF
Smiles CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 60 mg/mL ( (199.7 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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