Home Transmembrane Transporters ADC Cytotoxin inhibitor - Calcium Channel chemical Dantrolene sodium For research use only.

Dantrolene sodium

Synonyms: F 440

Dantrolene sodium(F 440) acts as a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.

Dantrolene sodium Chemical Structure

Dantrolene sodium Chemical Structure

CAS No. 14663-23-1

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Biological Activity

Description Dantrolene sodium(F 440) acts as a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.
In vitro
In vitro

Treatment with a mixture of Thaps. and dantrolene during optogenetic stimulation (OS) of Schwann cells (SCs) significantly decreases the percentage of MBP-expressing SCs and, importantly, reduces the percentage of MBP-expressing SCs. Mixture of Thaps. and dantrolene decreases drastically the ΔF/F value in SCs.[1]
Cell Research Cell lines Schwann cells
Concentrations 600 nM
Incubation Time 4 h
Method

Thaps. + Dantrolene (600 nM, a ryanodine receptor antagonist) for 4 h prior to examining the intracellular Ca2+ levels of SCs. Representative inverted images of BABTA-1 AM fluorescence signals showing the intracellular Ca2+ on SCs.
In Vivo
In vivo

Dantrolene administration decreases plasma GLuc-SERCaMP activity and endogenous SERCaMP activity when compared to vehicle during ad lib high fat diet. Rats administered dantrolene gains less weight compared to vehicle treated rats, and have less caloric intake.

Chemical Information & Solubility

Molecular Weight 336.23 Formula

C14H9N4NaO5
CAS No. 14663-23-1 SDF --
Smiles C1C(=NC(=O)N1N=CC2=CC=C(O2)C3=CC=C(C=C3)[N+](=O)[O-])[O-].[Na+]
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 10 mg/mL ( (29.74 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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