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Glucosamine sulfate

Synonyms: D-Glucosaminesulfate, D-Glucosamine sulphate

Glucosamine sulfate (D-Glucosaminesulfate, D-Glucosamine sulphate) is a dietary supplement commonly used in the treatment of osteoarthritis. It is a type of glycosaminoglycan, which is a naturally occurring major component of joint cartilage and joint fluid.

Glucosamine sulfate Chemical Structure

Glucosamine sulfate Chemical Structure

CAS No. 29031-19-4

Purity & Quality Control

Batch: S385001 Water]55 mg/mL]false]DMSO]4 mg/mL]false]]]false Purity: 98%
98

Glucosamine sulfate Related Products

Biological Activity

Description Glucosamine sulfate (D-Glucosaminesulfate, D-Glucosamine sulphate) is a dietary supplement commonly used in the treatment of osteoarthritis. It is a type of glycosaminoglycan, which is a naturally occurring major component of joint cartilage and joint fluid.
In vitro
In vitro Glucosamine sulfate exerts a pronounced suppressive effect on MMPs in osteosarcoma cell lines in vitro[1]. Glucosamine suppresses the activation of T-lymphoblasts and dendritic cells in vitro as well as allogeneic mixed leukocyte reactivity in a dose-dependent manner. Glucosamine has been shown to inhibit nucleic acid and protein biosynthesis and irreversible damage to organelles in tumor cells, but not in normal cells[3].
Cell Research Cell lines MG-63 and SaOS-2 cells
Concentrations 0, 10, 50 and 100 μg/ml
Incubation Time 48 h
Method Cells are exposed to 0, 10, 50 and 100 μg/ml glucosamine sulfate for 48 h and treatment toxicity is determined through measurement of cell viability and proliferation. Relative gene expression of matrix metalloproteinase (MMP)-2, -3 and -9 is quantified by real-time polymerase chain reaction. Protein levels of MMP-2 and -9 are assessed by ELISA.
In Vivo
In vivo Glucosamine sulfate attenuates DSS-induced colitis symptoms, possibly by suppressing the NF-κB-mediated TNF-α and IL-1β production and neutrophil activation that contribute to intestinal barrier disruption in colitic mice[2]. Glucosamine administration prolongs allogeneic cardiac allograft survival in vivo[3].
Animal Research Animal Models C57BL/6 mice
Dosages 0, 0.05, and 0.10% (w/w)
Administration oral
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03827161 Completed
Healthy Subject|Overweight
Fred Hutchinson Cancer Center
 August 1 2017 Phase 1

Chemical Information & Solubility

Molecular Weight 277.25 Formula

C6H13NO5.H2SO4
CAS No. 29031-19-4 SDF --
Smiles C(C(C(C(C(C=O)N)O)O)O)O.OS(=O)(=O)O
Storage (From the date of receipt)

In vitro
Batch:

Water : 55 mg/mL

DMSO : 4 mg/mL ( (14.42 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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