D-Galactose

Name: D-Galactose
Brand: Selleck Chemicals
SKU: S3849
Rating: 5 (4 reviews)

Synonyms: D-Galactopyranose, D-(+)-Galactose

Catalog No.S3849 Purity:98.56%

D-Galactose (D-Galactopyranose, D-(+)-Galactose) is an aldohexose that occurs naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins and is converted enzymatically into D-glucose for metabolism or polysaccharides for storage. It accelerates senescence in invertebrates and mammals and has been used as a model for aging.

D-Galactose Chemical Structure

CAS No. 59-23-4

Purity & Quality Control

Batch: Purity: 98.56%

98.56

D-Galactose Related Products

Related Products	BAPTA-AM Rat IgG2b isotype control-InVivo Blebbistatin Methyl-β-cyclodextrin (MβCD) AP-III-a4 (ENOblock) Carbazochrome sodium sulfonate (AC-17) Ursolic Acid Osthole NAD+ 4-Methylumbelliferone (4-MU) Dioscin Ethidium bromide Pitstop 2 Sesamin Bilobalide Formononetin Hesperidin Palmitic acid Azeliragon (TTP488) L-Mimosine Ademetionine Carbenoxolone Sodium GO-203 Vitexin N6022 Dp44mT Chlorogenic Acid Sphingosine Chrysin Coenzyme Q10 (CoQ10) Spermine Tetrahydrochloride 2-NBDG 2-NBDG D-Lin-MC3-DMA (MC3) Morin Hydrate Ethylenediaminetetraacetic acid Silibinin (NSC 651520) (+)-Fangchinoline Bergenin Spermine NB 598 DMNQ (20S)Ginsenoside Rg2 Farrerol EGCG Octaacetate D-(+)-Trehalose dihydrate Reboxetine mesylate E7820 Hydroxytyrosol Evofosfamide (TH-302) Bromhexine HCl 5-hydroxytryptophan (5-HTP) Inosine D-Mannose Anethole trithione Sodium Nitroprusside Dihydrate Alendronic Acid 2,4-Pyridinedicarboxylic acid GSK805 ADP Acipimox Curcumin analog C1 Trimetazidine 2,2,2-Tribromoethanol Sulfopin N-Acetylneuraminic acid Quinacrine Dihydrochloride Dihydrate L-methionine Stigmasterol Oleanonic Acid Substance P TFA Achyranthes bidentata root Extract Ginsenoside Rg3 Phyllanthus Urinaria Extract NSI-189 SR8278 Lycopene Trometamol hydrochloride 1-Methyl-3-nitro-1-nitrosoguanidine (MNNG) Ureidosuccinic acid Tea polyphenol Fructose (+)-JQ1 carboxylic acid Ligustilide Polybrene (Hexadimethrine Bromide) Pinoresinol diglucoside 4-HNE (4-Hydroxynonenal) Iron Dextran Sodium Picosulfate IM-54 Disufenton sodium Troxipide Orcinol glucoside Diludine 20R-Camptothecin (+)-Usniacin 3-Indolebutyric acid (IBA) HEPES Cremophor EL BMS-986176 DTT (Dithiothreitol) Esculin Methyl Eugenol Polyinosinic acid-polycytidylic acid L-(-)-Glucose 1-Hydroxy-2-naphthoic acid Azomycin 3-Hydroxybenzoic acid Emlenoflast (MCC-7840) β-Alanine β-Sitosterol Rat IgG1 isotype control-InVivo Aminomalonic acid Helecin BRM/BRG1 ATP Inhibitor-1 23-Hydroxybetulinic acid PZ-2891 Toosendanin 1,2-Propanediol Epibrassinolide Cyanidin-3-O-glucoside chloride Dihydrotanshinone I Gracillin Sodium Pyruvate Itaconic acid FH1 Cinnamic acid Guanidine HCl Triethylenetetramine 2HCl Molsidomine Calcium D-saccharate tetrahydrate Creatine monohydrate DL-Dopa FPH1 5'-Adenylic acid Acetamide ML329 Pterostilbene Kinetin Acetyl Resveratrol GSK4112 LTI-291 Plantamajoside Anhydroicaritin BZ1 Phloretic acid Anemoside B4 EGTA Sucralose 6-Chloropurine Glucosamine hydrochloride Sinoacutine 2,4-Dihydroxyacetophenone Stearic acid Stevioside Morin PMPA tetrasodium salt L-Hydroorotic acid Irigenin Behenic Acid CTX-0294885 Fudosteine (R)-(-)-JQ1 Enantiomer 2'-Deoxyguanosine monohydrate L-Tryptophanamide Hydrochloride β-Cyclodextrin 3-Indolepropionic acid DL-Citrulline Sclareol Methyl protocatechuate Sodium nitroprusside N-Nitrosodiethylamine Deoxyaconitine N-Acetyl-L-methionine Sinapine thiocyanate Sodium succinate Senkyunolide A L-Tryptophan Swertiamarin Octyl gallate Brassinazole	Click to Expand
Related Compound Libraries	FDA-approved Drug Library Natural Product Library Bioactive Compound Library-I Express-Pick Library	Click to Expand

Biological Activity

Description	D-Galactose (D-Galactopyranose, D-(+)-Galactose) is an aldohexose that occurs naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins and is converted enzymatically into D-glucose for metabolism or polysaccharides for storage. It accelerates senescence in invertebrates and mammals and has been used as a model for aging.

In vitro
In vitro	D-Galactose (D-gal) can induce oxidative stress in non-cancer cells and result in cell damage by disturbing glucose metabolism. D-Gal treatment can transcriptionally up-regulate the genes relevant to necroptosis (Bmf, Bnip3) and autophagy (Atg5, TIGAR) but not the genes related to apoptosis (Caspase3, Bax, and p53). D-Gal does not activate Caspase-3, but prompts puncta-like GFP–LC3 distribution, an indicator for activated autophagy^[1].
Cell Research	Cell lines	Mouse neuroblastoma cell line Neuro2a (N2a), human neuroblastoma cell line SH-SY5Y, human prostate cancer cell line PC-3 and mouse fibroblast cell line NIH3T3; Human hepatoma cell line HepG2 and human hepatocyte cell line LO2
	Concentrations	0-60 g/L
	Incubation Time	24 h
	Method	Mouse neuroblastoma cell line Neuro2a (N2a), human neuroblastoma cell line SH-SY5Y, human prostate cancer cell line PC-3 and mouse fibroblast cell line NIH3T3 are cultured in DMEM supplemented with 10% FBS, 100 U/ml penicillin, and 100 mg/ml streptomycin. Human hepatoma cell line HepG2 and human hepatocyte cell line LO2 are cultured in RPMI 1640 with 10% FBS. Cells are maintained at 37℃ with 5% CO2, and treated with D-gal or glucose in the concentrations and the time periods. Morphological assessments are conducted under microscope. Cell viability is evaluated by MTT assay.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT05319262	Completed	Noise Exposure\|Sleep Disturbance\|Sleep Hygiene\|Metabolic Disturbance\|Cognitive Change	Göteborg University\|University of Pennsylvania\|University of Manitoba	April 24 2022	Not Applicable

References

[1] Li N, et al. J Cell Biochem. 2011, 112(12):3834-44.

Chemical Information & Solubility

Molecular Weight	180.16	Formula	C₆H₁₂O₆
CAS No.	59-23-4	SDF	Download D-Galactose SDF
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 36 mg/mL ( (199.82 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 36 mg/mL

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):