Home Neuronal Signaling AChR agonist - Dopamine Receptor antagonist CNO (Clozapine N-oxide) For research use only.

CNO (Clozapine N-oxide)

CNO (Clozapine N-oxide) is a metabolite of Clozapine (GLXC-06516) and an agonist of human muscarinic designer receptors (Designer Receptors Exclusively Activated by Designer Drugs, DREADDs). Clozapine is a potent dopamine (DA) antagonist and a selective muscarinic M4 receptor agonist.Solutions are unstable and should be fresh-prepared.

CNO (Clozapine N-oxide) Chemical Structure

CNO (Clozapine N-oxide) Chemical Structure

CAS No. 34233-69-7

Purity & Quality Control

CNO (Clozapine N-oxide) Related Products

Signaling Pathway

AChR Signaling Pathways

AChR Signaling Pathway

Biological Activity

Description CNO (Clozapine N-oxide) is a metabolite of Clozapine (GLXC-06516) and an agonist of human muscarinic designer receptors (Designer Receptors Exclusively Activated by Designer Drugs, DREADDs). Clozapine is a potent dopamine (DA) antagonist and a selective muscarinic M4 receptor agonist.Solutions are unstable and should be fresh-prepared.
Targets
DREADD [1] Dopamine receptor [2] muscarinic M4 receptor [1]
In vitro
In vitro

CNO is a synthetic small molecule actuator for muscarinic acetylcholine DREADDs.
In Vivo
In vivo

Clozapine N-oxide (CNO), an agonist of human muscarinic designer receptor (DREADDs), is converted to clozapine and exerts clozapine-like behavioral effects in both mice and rats further emphasizes the need for appropriate control groups in studies employing DREADDs.[4]
Animal Research Animal Models standard laboratory rats and mice
Dosages 1.0, 3.2, 10.0 mg/kg for rats; 1.25, 2.5, 5.0, 10.0, 20.0 mg/kg for mice
Administration i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00372242 Completed
Mild and Moderate Malnourished Children
International Centre for Diarrhoeal Disease Research Bangladesh
 December 2000 Not Applicable

Chemical Information & Solubility

Molecular Weight 342.82 Formula

C18H19ClN4O
CAS No. 34233-69-7 SDF --
Smiles C[N+]1([O-])CCN(CC1)C2=NC3=C(NC4=CC=CC=C24)C=CC(=C3)Cl
Storage (From the date of receipt) 3 years -20°C powder Solutions are unstable. Prepare fresh or purchase small, pre-packaged sizes. Repackage upon receipt.

In vitro
Batch:

DMSO : 68 mg/mL ( (198.35 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 68 mg/mL

Ethanol : 8 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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