|
Toll Free: (877) 796-6397 -- USA and Canada only -- |
Fax: +1-832-582-8590 Orders: +1-832-582-8158 |
Tech Support: +1-832-582-8158 Ext:3 Please provide your Order Number in the email. |
Technical Data
| Formula | C18H19ClN4O |
|||
| Molecular Weight | 342.82 | CAS No. | 34233-69-7 | |
| Solubility (25°C)* | In vitro | DMSO | 68 mg/mL (198.35 mM) | |
| Water | 68 mg/mL (198.35 mM) | |||
| Ethanol | 8 mg/mL (23.33 mM) | |||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
||||
Preparing Stock Solutions
Biological Activity
| Description | CNO (Clozapine N-oxide) is a metabolite of Clozapine (GLXC-06516) and an agonist of human muscarinic designer receptors (Designer Receptors Exclusively Activated by Designer Drugs, DREADDs). Clozapine is a potent dopamine (DA) antagonist and a selective muscarinic M4 receptor agonist.Solutions are unstable and should be fresh-prepared. | |||
|---|---|---|---|---|
| Targets |
|
|||
| In vitro | CNO is a synthetic small molecule actuator for muscarinic acetylcholine DREADDs. |
|||
| In vivo | Clozapine N-oxide (CNO), an agonist of human muscarinic designer receptor (DREADDs), is converted to clozapine and exerts clozapine-like behavioral effects in both mice and rats further emphasizes the need for appropriate control groups in studies employing DREADDs.[4] |
Protocol (from reference)
| Animal Study: |
|
|---|
References
Selleck's CNO (Clozapine N-oxide) has been cited by 12 publications
| Distinct eLPBChAT projections for methamphetamine withdrawal anxiety and primed reinstatement of conditioned place preference [ Theranostics, 2024, 14(7):2881-2896] | PubMed: 38773977 |
| Distinct eLPBChAT projections for methamphetamine withdrawal anxiety and primed reinstatement of conditioned place preference [ Theranostics, 2024, 14(7):2881-2896] | PubMed: 38773977 |
| Pyruvate dehydrogenase complex E1 subunit α crotonylation modulates cocaine-associated memory through hippocampal neuron activation [ Cell Rep, 2024, 43(8):114529] | PubMed: 39046876 |
| Projection neurons from medial entorhinal cortex to basolateral amygdala are critical for the retrieval of morphine withdrawal memory [ iScience, 2024, 27(7):110239] | PubMed: 39021787 |
| Stress-induced red nucleus attenuation induces anxiety-like behavior and lymph node CCL5 secretion [ Nat Commun, 2023, 10.1038/s41467-023-42814-1] | PubMed: 37903803 |
| Nucleus accumbens circuit disinhibits lateral hypothalamus glutamatergic neurons contributing to morphine withdrawal memory in male mice [ Nat Commun, 2023, 14(1):71] | PubMed: 36604429 |
| Stress-induced red nucleus attenuation induces anxiety-like behavior and lymph node CCL5 secretion [ Nat Commun, 2023, 14(1):6923] | PubMed: 37903803 |
| Tet2 acts in the lateral habenula to regulate social preference in mice [ Cell Rep, 2023, 42(7):112695] | PubMed: 37402169 |
| Tet2 acts in the lateral habenula to regulate social preference in mice [ Cell Rep, 2023, 42(7):112695] | PubMed: 37402169 |
| Excitatory neurons in the lateral parabrachial nucleus mediate the interruptive effect of inflammatory pain on a sustained attention task [ J Transl Med, 2023, 21(1):896] | PubMed: 38072957 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.