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Schisandrin A AdipoR agonist

Cat.No.S3822

Schisandrin A (Sch A, Deoxyschizandrin, Wuweizisu A) is an active component of Schisandrae Fructus with liver-protective, antitumor, and antioxidant activities. It is an agonist of the adiponectin receptor 2 (AdipoR2) with the IC50 value of 3.5 μM.
Schisandrin A AdipoR agonist Chemical Structure

Chemical Structure

Molecular Weight: 416.51

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Quality Control

Batch: S382201 DMSO]83 mg/mL]false]]]false]]]false Purity: 99.89%
99.89

Solubility

In vitro
Batch:

DMSO : 83 mg/mL (199.27 mM)
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In vivo
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Chemical Information, Storage & Stability

Molecular Weight 416.51 Formula

C24H32O6

 Storage (From the date of receipt)
CAS No. 61281-38-7 Download SDF Storage of Stock Solutions

Synonyms Deoxyschizandrin, Wuweizisu A Smiles CC1CC2=CC(=C(C(=C2C3=C(C(=C(C=C3CC1C)OC)OC)OC)OC)OC)OC

Mechanism of Action

Targets/IC50/Ki
AdipoR2
3.5 μM
In vitro
Schisandrin A significantly suppresses the lipopolysaccharide (LPS)-induced production of the key pro-inflammatory mediators nitric oxide (NO) and prostaglandin E2 by suppressing the expression of inducible NO synthase and cyclooxygenase-2 at the mRNA and protein levels in RAW 264.7 macrophages. It is demonstrated to reduce the LPS-induced secretion of pro-inflammatory cytokines, including tumor necrosis factor-α and interleukin-1β; this is accompanied by a simultaneous decrease in the respective mRNA and protein levels in the macrophages. In addition, the LPS- induced translocation of nuclear factor-κB (NF-κB), as well as activation of mitogen-activated protein kinases (MAPKs) and phosphatidylinositol-3 kinase (PI3K)/Akt pathways are inhibited by this compound. These results suggest that this chemical has a protective effect against LPS-induced inflammatory and oxidative responses in RAW 264.7 cells by inhibiting the NF-κB, MAPK and PI3K/Akt pathways. It possesses anti-inflammatory activities and excellent Nrf2-induction or ROS-scavenging abilities. This compound can inhibit the replication of four serotypes of DENV in a concentration- and time-dependent manner, with an effective half-maximal effective concentration 50% (EC50) value of 28.1 ± 0.42 μM against DENV serotype type 2 without significant cytotoxicity.
In vivo
Schisandrin A has proven beneficial in preventing cell damage in the pathogenesis of central nervous system diseases, including ischemia. This compound can effectively protect mice from DENV infection by reducing disease symptoms and mortality of DENV-infected mice. It stimulates IFN-mediated antiviral responses in vivo.
References
  • [4] https://pubmed.ncbi.nlm.nih.gov/23691032/

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