Home NF-κB NF-κB inhibitor PDTC (Pyrrolidinedithiocarbamate ammonium) For research use only.

PDTC (Pyrrolidinedithiocarbamate ammonium)

Synonyms: APDC, Pyrrolidine dithiocarbamic acid ammonium salt

PDTC (Pyrrolidinedithiocarbamate ammonium) is a potent nuclear factor-κB (NF-κB) inhibitor that inhibits IκB phosphorylation, blocks NF-κB translocation to the nucleus and reduces the expression of downstream cytokines.

PDTC (Pyrrolidinedithiocarbamate ammonium) Chemical Structure

PDTC (Pyrrolidinedithiocarbamate ammonium) Chemical Structure

CAS No. 5108-96-3

Purity & Quality Control

PDTC (Pyrrolidinedithiocarbamate ammonium) Related Products

Signaling Pathway

NF-κB Signaling Pathways

NF-κB Signaling Pathway

Biological Activity

Description PDTC (Pyrrolidinedithiocarbamate ammonium) is a potent nuclear factor-κB (NF-κB) inhibitor that inhibits IκB phosphorylation, blocks NF-κB translocation to the nucleus and reduces the expression of downstream cytokines.
Targets
NF-κB [1]
In vitro
In vitro Ammonium pyrrolidine dithiocarbamate (PDTC) can inhibit the role of NF-κB by inhibiting IκB phosphorylation, thus blocking NF-κB translocation to the nucleus, reducing the expression of downstream cytokines[1].
Experimental Result Images Methods Biomarkers Images PMID
Western blot CCR2 / CCR5 / CXCR4 p-IKKβ / IKKβ / p-IκBα / IκBα p-p65 / p65 / p50 10716998
Immunofluorescence p65 / p50 29956738

Chemical Information & Solubility

Molecular Weight 164.29 Formula

C5H9NS2.H3N
CAS No. 5108-96-3 SDF Download PDTC (Pyrrolidinedithiocarbamate ammonium) SDF
Smiles C1CCN(C1)C(=S)[S-].[NH4+]
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 32 mg/mL ( (194.77 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 32 mg/mL

Ethanol : 32 mg/mL


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In vivo
Batch:

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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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