|
Toll Free: (877) 796-6397 -- USA and Canada only -- |
Fax: +1-832-582-8590 Orders: +1-832-582-8158 |
Tech Support: +1-832-582-8158 Ext:3 Please provide your Order Number in the email. |
Technical Data
| Formula | C5H9NS2.H3N |
|||
| Molecular Weight | 164.29 | CAS No. | 5108-96-3 | |
| Solubility (25°C)* | In vitro | DMSO | 32 mg/mL (194.77 mM) | |
| Water | 32 mg/mL (194.77 mM) | |||
| Ethanol | 32 mg/mL (194.77 mM) | |||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
||||
Preparing Stock Solutions
Biological Activity
| Description | PDTC (Pyrrolidinedithiocarbamate ammonium) is a potent nuclear factor-κB (NF-κB) inhibitor that inhibits IκB phosphorylation, blocks NF-κB translocation to the nucleus and reduces the expression of downstream cytokines. | |
|---|---|---|
| Targets |
|
|
| In vitro | Ammonium pyrrolidine dithiocarbamate (PDTC) can inhibit the role of NF-κB by inhibiting IκB phosphorylation, thus blocking NF-κB translocation to the nucleus, reducing the expression of downstream cytokines[1]. |
Protocol (from reference)
| Animal Study:[1] |
|
|---|
Selleck's PDTC (Pyrrolidinedithiocarbamate ammonium) has been cited by 91 publications
| Prevotella copri promotes vascular calcification via lipopolysaccharide through activation of NF-κB signaling pathway [ Gut Microbes, 2024, 16(1):2351532] | PubMed: 38727248 |
| Prevotella copri promotes vascular calcification via lipopolysaccharide through activation of NF-κB signaling pathway [ Gut Microbes, 2024, 16(1):2351532] | PubMed: 38727248 |
| Tert promotes cardiac regenerative repair after MI through alleviating ROS-induced DNA damage response in cardiomyocyte [ Cell Death Discov, 2024, 10(1):381] | PubMed: 39187478 |
| Anti-tumor effects of telmisartan in glioma-astrocyte non-contact co-cultures: A critical role of astrocytic IL-6-mediated paracrine growth promotion [ Int Immunopharmacol, 2024, 139:112707] | PubMed: 39032472 |
| Helicobacter pylori with trx1 high expression promotes gastric diseases via upregulating the IL23A/NF-κB/IL8 pathway [ Helicobacter, 2024, 29(2):e13072] | PubMed: 38686467 |
| Chemotherapy-initiated cysteine-rich protein 61 decreases acute B-lymphoblastic leukemia chemosensitivity [ J Cancer Res Clin Oncol, 2024, 150(3):159] | PubMed: 38530432 |
| A20 haploinsufficiency disturbs immune homeostasis and drives the transformation of lymphocytes with permissive antigen receptors [ Sci Adv, 2024, 10(34):eadl3975] | PubMed: 39167656 |
| Increased α-HB links colorectal cancer and diabetes by potentiating NF-κB signaling [ Mol Metab, 2023, 75:101766] | PubMed: 37406987 |
| Transgelin promotes lung cancer progression via activation of cancer-associated fibroblasts with enhanced IL-6 release [ Oncogenesis, 2023, 12(1):18] | PubMed: 36990991 |
| Telmisartan inhibits microglia-induced neurotoxic A1 astrocyte conversion via PPARγ-mediated NF-κB/p65 degradation [ Int Immunopharmacol, 2023, 123:110761] | PubMed: 37544025 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.