Home Others Other chemical Hydroxytyrosol Acetate For research use only.

Hydroxytyrosol Acetate

Synonyms: HTy-Ac

Hydroxytyrosol acetate (HTy-Ac), an extra virgin olive oil (EVOO) polyphenol, exhibits antioxidant and anti-inflammatory effects.

Hydroxytyrosol Acetate Chemical Structure

Hydroxytyrosol Acetate Chemical Structure

CAS No. 69039-02-7

Purity & Quality Control

Batch: S384801 DMSO]39 mg/mL]false]]]false]]]false Purity: 99.66%
99.66

Hydroxytyrosol Acetate Related Products

Biological Activity

Description Hydroxytyrosol acetate (HTy-Ac), an extra virgin olive oil (EVOO) polyphenol, exhibits antioxidant and anti-inflammatory effects.
In vitro
In vitro Hydroxytyrosol acetate significantly preventes t-BHP-induced OPA1 cleavage as well as the induction of Afg3l2. The significant morphology change in mitochondria induced by t-BHP is also normalized by Hydroxytyrosol acetate. Analysis of mitochondrial function reveals significant protection by hydroxytyrosol acetate on mitochondrial basal, maximal, spare respiration and complex activities. Hydroxytyrosol acetate works as an effective nutrient preventing OPA1 cleavage, mitochondrial dysfunction and muscle cell degeneration[2].
Cell Research Cell lines C2C12 cell
Concentrations 1, 10 and 50 μM
Incubation Time 24 h
Method C2C12 myotubes are treated with Hydroxytyrosol acetate at doses of 1, 10 and 50 μM for 24 h, followed by 100 μM t-BHP for an additional 24 h. The protective effects of Hydroxytyrosol acetate on mitochondrial membrane potential and cell viability are analyzed.
In Vivo
In vivo Hydroxytyrosol acetate administered orally inhibits platelet aggregation in rats and that a decrease in thromboxane synthesis along with an increase in nitric oxide production contribute to this effect[1].
Animal Research Animal Models Male Wistar rats
Dosages 1, 5, 10, 20, 50, and 100 mg/kg per day
Administration p.o.

Chemical Information & Solubility

Molecular Weight 196.20 Formula

C10H12O4
CAS No. 69039-02-7 SDF Download Hydroxytyrosol Acetate SDF
Smiles CC(=O)OCCC1=CC(=C(C=C1)O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 39 mg/mL ( (198.77 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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