5-Aminolevulinic acid HCl

Synonyms: 5-ALA hydrochloride

5-Aminolevulinic Acid HCl(5-ALA hydrochloride) is an intermediate in the porphyrin synthesis pathway, used as a photosensitizing agent and a antineoplastic agent.

5-Aminolevulinic acid HCl Chemical Structure

5-Aminolevulinic acid HCl Chemical Structure

CAS No. 5451-09-2

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5-Aminolevulinic acid HCl Related Products

Biological Activity

Description 5-Aminolevulinic Acid HCl(5-ALA hydrochloride) is an intermediate in the porphyrin synthesis pathway, used as a photosensitizing agent and a antineoplastic agent.
In vitro
In vitro

5-aminolevulinic acid (5-ALA)-Photodynamic therapy (PDT) results in down regulation of nuclear factor kappa B (NFkappaB) and baculovirus inhibitor-of-apoptosis repeat containing-3 (BIRC-3) protein. 5-aminolevulinic acid (5-ALA)-Photodynamic therapy (PDT) causes increase in Bax:Bcl-2 ratio and mitochondrial release of cytochrome c and apoptosis-inducing factor (AIF). [1] 5-aminolevulinic acid yields reactive oxygen species upon metal-catalyzed oxidation and causes in vivo and in vitro impairment of rat liver mitochondria and DNA damage. 5-aminolevulinic acid induces a dose-dependent damage in nuclear and mitochondrial DNA in human SVNF fibroblasts and rat PC12 cells. [2] 5-aminolevulinic acid dose-dependently decreases cAMP levels (maximal inhibition of 38%, at 1 mM), due to an inhibition of basaladenylate cyclase activity. 5-aminolevulinic acid also inhibits fluoride- and Gpp(NH)p-stimulated, but not the forskolin-stimulated adenylate cyclase activity. 5-aminolevulinic acid also inhibits the activity of adenylate cyclase in membranes isolated from rat cortex and striatum and from human cortex. [3] 5-aminolevulinic acid (0-3mM) dose-dependently inhibits glutamate uptake by astrocyte cultures. 5-aminolevulinic acid significantly reduces both the K(m) and V(max) of glutamate uptake indicating an uncompetitive inhibition. 5-aminolevulinic acid significantly increases astrocyte lipoperoxidation in astrocytes incubated under these conditions. [4] 5-aminolevulinic acid mediated sonodynamic therapy exhibits synergistic apoptotic effects on THP-1 macrophages, involving excessive intracellular reactive oxygen species generation and MMP loss. [5]

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04626661 Completed
Mitochondrial Oxygenation Measurement|Measurement Error|Healthy
Sanquin-LUMC J.J van Rood Center for Clinical Transfusion Research|Leiden University Medical Center
June 15 2020 --
NCT00241670 Completed
Brain Cancer|Brain Tumors|Cancer of Brain|Primary Brain Tumors|Brain Tumor Primary
medac GmbH
October 1999 Phase 3

Chemical Information & Solubility

Molecular Weight 167.59 Formula

C5H9NO3.HCl

CAS No. 5451-09-2 SDF Download 5-Aminolevulinic acid HCl SDF
Smiles C(CC(=O)O)C(=O)CN.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 34 mg/mL ( (202.87 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 34 mg/mL

Ethanol : 10 mg/mL


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