4-Hydroxybenzoic acid

Name: 4-Hydroxybenzoic acid
Brand: Selleck Chemicals
SKU: S3754
Rating: 5 (1 reviews)

Synonyms: p-hydroxybenzoic acid, PHBA, para-Hydroxybenzoic acid, 4-hydroxybenzoate

Catalog No.S3754 Purity:98%

4-Hydroxybenzoic acid (p-hydroxybenzoic acid, PHBA, para-Hydroxybenzoic acid, 4-hydroxybenzoate), also known as p-hydroxybenzoic acid (PHBA), is a phenolic derivative of benzoic acid and widely used in organic synthesis. It is the most widely distributed aromatic organic acid in the vegetable kingdom.

4-Hydroxybenzoic acid Chemical Structure

CAS No. 99-96-7

Purity & Quality Control

Batch: S375401 DMSO]27 mg/mL]false]]]false]]]false Purity: 98%

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Biological Activity

Description	4-Hydroxybenzoic acid (p-hydroxybenzoic acid, PHBA, para-Hydroxybenzoic acid, 4-hydroxybenzoate), also known as p-hydroxybenzoic acid (PHBA), is a phenolic derivative of benzoic acid and widely used in organic synthesis. It is the most widely distributed aromatic organic acid in the vegetable kingdom.

In Vivo
In vivo	Subcutaneous administration of PHBA produces an estrogen-like effect in CD1 mice inducing vaginal cornification and increasing the uterine weight for both immature female mice and ovariectomized animals. These effects are dose-dependent^[1].
Animal Research	Animal Models	CD1 mice
	Dosages	0.5, 5, 50, and 500 mg/100 g
	Administration	s.c.

References

[1] Lemini C, et al. Environ Res. 1997, 75(2):130-4.

Chemical Information & Solubility

Molecular Weight	138.12	Formula	C₇H₆O₃
CAS No.	99-96-7	SDF	Download 4-Hydroxybenzoic acid SDF
Smiles	C1=CC(=CC=C1C(=O)O)O
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 27 mg/mL ( (195.48 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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