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Catalog No. Product Name Information Product Use Citations Product Validations
S2449 Forskolin (Colforsin) Forskolin (Colforsin) is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physiology. Forskolin also activates PXR and FXR activity. Forskolin stimulates autophagy.
Circulation, 2024, 149(18):1435-1456
Cell Stem Cell, 2024, S1934-5909(24)00048-1
Sci Bull (Beijing), 2024, S2095-9273(24)00799-0
S8283 SQ22536 SQ22536 (9-(tetrahydrofuran-2-yl)-9h-purin-6-amine) is an inhibitor of adenylyl cyclase with an IC50 of 1.4 μM. It can inhibit PGE1-stimulated increases in cAMP levels in intact human platelets.
J Nanobiotechnology, 2024, 22(1):85
Invest Ophthalmol Vis Sci, 2024, 65(3):10
Kaohsiung J Med Sci, 2023, 10.1002/kjm2.12722
S7499 ESI-09 ESI-09 is a specific exchange protein directly activated by cAMP (EPAC) inhibitor with IC50 of 3.2 μM and 1.4 μM for EPAC1 and EPAC2, respectively, >100-fold selectivity over PKA.
J Biol Chem, 2023, 299(6):104749
J Biol Chem, 2023, 299(6):104749
Oxid Med Cell Longev, 2021, 2021:9921982
S8415 PACAP 1-38 PACAP 1-38 (Pituitary Adenylate Cyclase Activating Polypeptide 38) is a highly potent PACAP receptor agonist (Kd = 100 pM). It stimulates adenylate cyclase and phagocytosis.
Biomed Pharmacother, 2024, 179:117427
Invest Ophthalmol Vis Sci, 2022, 63(3):18
Front Immunol, 2021, 12:714244
S4552 Bithionol Bithionol (Actamer) is a potent inhibitor of soluble adenylyl cyclase(sAC) with an IC50 of 4 μM and has antibacterial and anthelmintic properties along with algaecide activity.
iScience, 2023, 10.1016/j.isci.2023.106661
Cancer Lett, 2020, 479:100-111
Inflammation, 2019, 42(5):1530-1541
S8416 PACAP 6-38 acetate PACAP 6-38 acetate is a PACAP (pituitary adenylate cyclase-activating polypeptide) non-stimulating competitive antagonist with an IC50 value of 2 nM. It also acts as a functional CARTp antagonist in vivo.
Front Immunol, 2021, 12:714244
S7500 HJC0350 HJC0350 is a potent and selective EPAC2 inhibitor with IC50 of 0.3 μM, exhibiting no inhibition on Epac1.
J Mol Cell Biol, 2019, 11(5):395-407
A2385 Zelminemab (Anti-PAC1) Zelminemab (AMG-301) is a human monoclonal antibody that inhibits the PACAP type I (PAC1) receptor. MW: 145.5 kD.
S3382 ESI-05 ESI-05 (NSC 116966) is a specific EPAC2 (exchange protein directly activated by cAMP 2) antagonist with IC50 of 0.4 µM. ESI-05 (NSC 116966) inhibits cAMP-mediated activation of EPAC2 and EAPC2 mediated Rap1 activation.
S8414 PACAP 1-27 Pituitary adenylate cyclase activating polypeptide (PACAP 1-27) is a potent PACAP receptor antagonist.
S0837 HJC0197 HJC0197 is a selective Epac 1/2 dual antagonists with an IC50 of 5.9 μM for Epac2.
S6850 NE 52-QQ57 NE 52-QQ57 is a selective, and orally available antagonist of G-protein coupled receptor 4 (GPR4) with IC50 of 0.07 μM. NE 52-QQ57 effectively blocks GPR4-mediated cAMP accumulation with IC50 of 26.8 nM in HEK293 cells. The antagonism of GPR4 with NE 52-QQ57 significantly inhibits the AGE-induced increased expression of several key inflammatory cytokines and signaling molecules, including tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, inducible nitric oxide synthase (iNOS), nitric oxide (NO), cyclooxygenase 2 (COX2), and prostaglandin E2 (PGE2).
Exp Hematol Oncol, 2024, 13(1):13
S6478 Fipexide hydrochloride Fipexide (hydrochloride) is a psychoactive drug of the piperazine class.
S0451 ST034307 ST034307 is a potent and selective inhibitor of adenylyl cyclase 1 (AC1) with IC50 of 2.3 μM.
S8283 SQ22536 SQ22536 (9-(tetrahydrofuran-2-yl)-9h-purin-6-amine) is an inhibitor of adenylyl cyclase with an IC50 of 1.4 μM. It can inhibit PGE1-stimulated increases in cAMP levels in intact human platelets.
J Nanobiotechnology, 2024, 22(1):85
Invest Ophthalmol Vis Sci, 2024, 65(3):10
Kaohsiung J Med Sci, 2023, 10.1002/kjm2.12722
S7499 ESI-09 ESI-09 is a specific exchange protein directly activated by cAMP (EPAC) inhibitor with IC50 of 3.2 μM and 1.4 μM for EPAC1 and EPAC2, respectively, >100-fold selectivity over PKA.
J Biol Chem, 2023, 299(6):104749
J Biol Chem, 2023, 299(6):104749
Oxid Med Cell Longev, 2021, 2021:9921982
S4552 Bithionol Bithionol (Actamer) is a potent inhibitor of soluble adenylyl cyclase(sAC) with an IC50 of 4 μM and has antibacterial and anthelmintic properties along with algaecide activity.
iScience, 2023, 10.1016/j.isci.2023.106661
Cancer Lett, 2020, 479:100-111
Inflammation, 2019, 42(5):1530-1541
S8416 PACAP 6-38 acetate PACAP 6-38 acetate is a PACAP (pituitary adenylate cyclase-activating polypeptide) non-stimulating competitive antagonist with an IC50 value of 2 nM. It also acts as a functional CARTp antagonist in vivo.
Front Immunol, 2021, 12:714244
S7500 HJC0350 HJC0350 is a potent and selective EPAC2 inhibitor with IC50 of 0.3 μM, exhibiting no inhibition on Epac1.
J Mol Cell Biol, 2019, 11(5):395-407
S3382 ESI-05 ESI-05 (NSC 116966) is a specific EPAC2 (exchange protein directly activated by cAMP 2) antagonist with IC50 of 0.4 µM. ESI-05 (NSC 116966) inhibits cAMP-mediated activation of EPAC2 and EAPC2 mediated Rap1 activation.
S8414 PACAP 1-27 Pituitary adenylate cyclase activating polypeptide (PACAP 1-27) is a potent PACAP receptor antagonist.
S6850 NE 52-QQ57 NE 52-QQ57 is a selective, and orally available antagonist of G-protein coupled receptor 4 (GPR4) with IC50 of 0.07 μM. NE 52-QQ57 effectively blocks GPR4-mediated cAMP accumulation with IC50 of 26.8 nM in HEK293 cells. The antagonism of GPR4 with NE 52-QQ57 significantly inhibits the AGE-induced increased expression of several key inflammatory cytokines and signaling molecules, including tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, inducible nitric oxide synthase (iNOS), nitric oxide (NO), cyclooxygenase 2 (COX2), and prostaglandin E2 (PGE2).
Exp Hematol Oncol, 2024, 13(1):13
S6478 Fipexide hydrochloride Fipexide (hydrochloride) is a psychoactive drug of the piperazine class.
S0451 ST034307 ST034307 is a potent and selective inhibitor of adenylyl cyclase 1 (AC1) with IC50 of 2.3 μM.
A2385 Zelminemab (Anti-PAC1) Zelminemab (AMG-301) is a human monoclonal antibody that inhibits the PACAP type I (PAC1) receptor. MW: 145.5 kD.
S2449 Forskolin (Colforsin) Forskolin (Colforsin) is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physiology. Forskolin also activates PXR and FXR activity. Forskolin stimulates autophagy.
Circulation, 2024, 149(18):1435-1456
Cell Stem Cell, 2024, S1934-5909(24)00048-1
Sci Bull (Beijing), 2024, S2095-9273(24)00799-0
S0837 HJC0197 HJC0197 is a selective Epac 1/2 dual antagonists with an IC50 of 5.9 μM for Epac2.
S8415 PACAP 1-38 PACAP 1-38 (Pituitary Adenylate Cyclase Activating Polypeptide 38) is a highly potent PACAP receptor agonist (Kd = 100 pM). It stimulates adenylate cyclase and phagocytosis.
Biomed Pharmacother, 2024, 179:117427
Invest Ophthalmol Vis Sci, 2022, 63(3):18
Front Immunol, 2021, 12:714244

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