Home Neuronal Signaling AChR inhibitor Dehydroevodiamine hydrochloride For research use only.

Dehydroevodiamine hydrochloride

Dehydroevodiamine (DHE), a major phytochemical in fruits of Evodia rutaecarpa, can inhibit AChE. It has hypotensive and neuroprotective effects and modulates nitric oxide production.

Dehydroevodiamine hydrochloride Chemical Structure

Dehydroevodiamine hydrochloride Chemical Structure

CAS No. 111664-82-5

Purity & Quality Control

Batch: S382001 DMSO]37 mg/mL]false]]]false]]]false Purity: 99.94%
99.94

Dehydroevodiamine hydrochloride Related Products

Signaling Pathway

AChR Signaling Pathways

AChR Signaling Pathway

Biological Activity

Description Dehydroevodiamine (DHE), a major phytochemical in fruits of Evodia rutaecarpa, can inhibit AChE. It has hypotensive and neuroprotective effects and modulates nitric oxide production.
Targets
AChE [2]
In vitro
In vitro Dehydroevodiamine·HCl (DHED) treatment significantly recovers the decreases in the levels of neural cell adhesion molecule (NCAM) proteins caused by stress and the decreases in cell viability[1]. It decreases intracellular calcium levels in primary cortical neurons[2].
Cell Research Cell lines primary cortical neurons
Concentrations 0.5 and 1 µM
Incubation Time 4 h
Method Cells are cultured in a specified medium for neurons (neurobasal medium supplemented with B27 and penicillin-streptomycin (100 U/ml/100 mg/ml) at 37℃ and 5% CO2 and plated at a density of 5×104 cells/well on Deckgläser cover glasses coated with PLL (1 mg/ml) in the 12 well plates. Experiments are performed on 10-day cultures. After DHED (0.5 and 1 µM) and fluoxetine (0.5 µM) treatment for 4 hr, staurosporin (1 µM) are added for 1 hr.
In Vivo
In vivo Dehydroevodiamine·HCl (DHED) can improve stress-induced memory impairments and depression-like behaviors[1]. DHED significantly improves learning and memory in the Aβ1-42-infused rat model. Antiamnestic effects of DHED occur through an improvement of learning and memory and an inhibition of neuronal dysfunction in a scopolamine-induced amnesic rat model. Furthermore, Dehydroevodiamine·HCl (DHED) has hypotensive and neuroprotective effects and modulates nitric oxide production[2].
Animal Research Animal Models male Wistar rats
Dosages 10 mg/kg/day
Administration p.o.

Chemical Information & Solubility

Molecular Weight 337.8 Formula

C19H15N3O.HCl
CAS No. 111664-82-5 SDF Download Dehydroevodiamine hydrochloride SDF
Smiles CN1C2=CC=CC=C2C(=O)N3C1=C4C(=C5C=CC=CC5=N4)CC3.Cl
Storage (From the date of receipt)

In vitro
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DMSO : 37 mg/mL ( (109.53 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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