Home Endocrinology & Hormones Glucocorticoid Receptor agonist - Immunology & Inflammation related modulator Prednisolone For research use only.

Prednisolone

Synonyms: NSC-9900

Prednisolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.

Prednisolone Chemical Structure

Prednisolone Chemical Structure

CAS No. 50-24-8

Purity & Quality Control

Prednisolone Related Products

Biological Activity

Description Prednisolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
Targets
Glucocorticoid receptor [1]
In vitro
In vitro

Prednisolone (50 mg/kg, im) given 15 min before LPS-attenuated production of NO2- and NO3- by neutrophils and suppresses LPS-stimulated mRNA for NOS II in rat neutrophils. [1] Prednisolone reduces joint swelling through a mechanism associated with a reduction in IL-1beta and IL-6 protein and mRNA expression levels in SCW-induced arthritis rats. [2] Prednisolone's anti-inflammatory effects can be mediated by reducing cellular adhesion molecule (CAM) expression. Prednisolone (0.75 mg/kg) reduces macrophages (-59%, -57%), CD4(+) T-cells (-50%, -60%), CD8(+) T-cells (-58%, -48%), and eosinophils (-36%, -25%) in quadriceps and soleus muscles, respectively. Prednisolone-treated mice also exhibits decreased vascular P-selectin (-82%) and ICAM-1 (-52%) expression and fewer L-selectin (-79%) and ICAM-1 (-57%) expressing mononuclear cells in quadriceps. Prednisolone reduces sarcolemmal damage and degeneration as well in Dystrophin-deficient, mdx mice. [3]
In Vivo
In vivo

Prednisolone (5 mg/kg) causes alterations in diaphragmatic contractile properties and histological changes without fiber atrophy in rats. Prednisolone results in an increased number of diaphragmatic bundles in rats. [4] Prednisolone induces a significant decline of PL-pO2, while CoBF, CMs, CAPs, and ABRs revealed no change in guinea pigs. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06343792 Not yet recruiting
Steroid Refractory GVHD
ReAlta Life Sciences Inc.
 May 2024 Phase 2
NCT06377345 Not yet recruiting
Asthma|Asthma Attack|Asthma in Children|Asthma Acute|Asthma Chronic
SingHealth Polyclinics
 April 20 2024 Not Applicable
NCT06297486 Recruiting
Hemophilia A
Spark Therapeutics Inc.
 March 13 2024 Phase 3
NCT06119529 Recruiting
Healthy|Atopic Dermatitis
Eli Lilly and Company
 November 1 2023 Phase 1

Chemical Information & Solubility

Molecular Weight 360.44 Formula

C21H28O5
CAS No. 50-24-8 SDF Download Prednisolone SDF
Smiles CC12CC(C3C(C1CCC2(C(=O)CO)O)CCC4=CC(=O)C=CC34C)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 72 mg/mL ( (199.75 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 40 mg/mL

Water : Insoluble


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In vivo
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