Home MAPK Raf inhibitor Exarafenib For research use only.

Exarafenib

Synonyms: KIN-002787, KIN-2787, RAF/KIN_2787

Exarafenib(KIN-002787, KIN-2787, RAF/KIN_2787) is an orally-available, selective inhibitor of pan-RAF. Exarafenib is effective in RAF-dependent cancers, including all classes of BRAF alterations. Exarafenib suppresses MAPK signaling in RAF-dependent melanoma cell lines. KIN-2787 exhibits low nanomolar to picomolar potency against RAF1, BRAF, and ARAF with an IC50 of 0.06-3.46 nM with minimal activity towards non-RAF kinases.

Exarafenib Chemical Structure

Exarafenib Chemical Structure

CAS No. 2639957-39-2

Purity & Quality Control

Exarafenib Related Products

Signaling Pathway

Raf Signaling Pathways

Raf Signaling Pathway

Biological Activity

Description Exarafenib(KIN-002787, KIN-2787, RAF/KIN_2787) is an orally-available, selective inhibitor of pan-RAF. Exarafenib is effective in RAF-dependent cancers, including all classes of BRAF alterations. Exarafenib suppresses MAPK signaling in RAF-dependent melanoma cell lines. KIN-2787 exhibits low nanomolar to picomolar potency against RAF1, BRAF, and ARAF with an IC50 of 0.06-3.46 nM with minimal activity towards non-RAF kinases.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04913285 Recruiting
Solid Tumor Adult|Non-small Cell Lung Cancer|Melanoma
Kinnate Biopharma
 August 4 2021 Phase 1

Chemical Information & Solubility

Molecular Weight 521.58 Formula

C26H34F3N5O3
CAS No. 2639957-39-2 SDF Download Exarafenib SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (191.72 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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