FOX

Other Metabolism Related Inhibitors

Dehydrogenase Transferase DPP Aminopeptidase Procollagen C Proteinase P450 (e.g. CYP17) Phospholipase (e.g. PLA) Factor Xa PDE DHFR

Cat.No.	Product Name	Information	Product Use Citations	Product Validations
S8222	AS1842856	AS1842856 is a cell-permeable inhibitor that blocks the transcription activity of Foxo1 with IC50 of 33 nM. It could directly bind to the active Foxo1, but not the Ser256-phosphorylated form. AS1842856 suppresses autophagy.	Environ Int, 2025, 205:109862 Int Immunopharmacol, 2025, 162:115128 J Mol Cell Biol, 2025, mjaf021
E6471^New	JY-2	JY-2 is a selective and orally active inhibitor of the transcription factor forkhead box O1 (FoxO1). JY-2 suppresses FoxO1-driven transcriptional activity with an IC50 of 22 μM, and also exerts moderate inhibitory effects on FoxO3a and FoxO4. JY-2 also exhibits anti-diabetic properties.

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S8222

AS1842856

AS1842856 is a cell-permeable inhibitor that blocks the transcription activity of Foxo1 with IC50 of 33 nM. It could directly bind to the active Foxo1, but not the Ser256-phosphorylated form. AS1842856 suppresses autophagy.

Environ Int, 2025, 205:109862

Int Immunopharmacol, 2025, 162:115128

J Mol Cell Biol, 2025, mjaf021

E6471^New

JY-2

JY-2 is a selective and orally active inhibitor of the transcription factor forkhead box O1 (FoxO1). JY-2 suppresses FoxO1-driven transcriptional activity with an IC50 of 22 μM, and also exerts moderate inhibitory effects on FoxO3a and FoxO4. JY-2 also exhibits anti-diabetic properties.