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Melanoma

Modeling Agent

7,12-Dimethylbenz[a]anthracene

Drugs Approved

Dabrafenib Mesylate

Trametinib DMSO solvate

Chemotherapy ^[1]

ICIs

PD-1: Retifanlimab; Zimberelimab; Penpulimab; Prolgolimab; Tislelizumab; Camrelizumab; Sintilimab; Pembrolizumab; Nivolumab; Cetrelimab; Sasanlimab; Spartalizumab; Ezabenlimab; Pidilizumab

PD-L1: Sugemalimab; Durvalumab; Atezolizumab; INCB086550; Cosibelimab; Lodapolimab; Manelimab

CALT-4: Tremelimumab; Ipilimumab; Quavonlimab; Nurulimab

Anti-Angiogenesis ^[2]

VEGF: Bevacizumab

VEGFR: Lenvatinib; Nintedanib; Cabozantinib malate; Axitinib; Sunitinib malate; Sorafenib tosylate; Apatinib (YN968D1) mesylate; Vorolanib

FGFR: Lenvatinib; Golvatinib

PDGFR: Nintedanib; Imatinib Mesylate; Vorolanib

MMPs: Marimastat; Doxycycline

Targeted Therapy (A)

IL-2R: Daclizumab; Basiliximab; Camidanlumab

BRAF: Encorafenib; Exarafenib

Tubulin: Nab-Paclitaxel; Paclitaxel; Vindesine sulfate; Vincristine sulfate; Verubulin hydrochloride; Patupilone

DNA: TMZ; Dacarbazine; Cyclophosphamide; Evofosfamide

JAK1/2: Ruxolitinib

Targeted Therapy (B)

MEK/2: Selumetinib; Binimetinib; Cobimetinib; Trametinib DMSO solvate; Mirdametinib; Pimasertib; TAK-733; GDC-0623

ERK1/2: ASN007; Temuterkib; Ulixertinib; Ravoxertinib

4-1BB/CD137: Urelumab; Utomilumab

HDAC: Panobinostat; Tucidinostat; Romidepsin; Vorinostat; Entinostat; PCI-34051

CSCs Marker ^[2]

ABCG2: Ko143; RG14620; YHO-13177; KS176; 5,7-Dimethoxyflavone

ALDH: Disulfiram; Daidzin; NCT-501; Alda 1; CM10; 3-Hydroxybenzaldehyde; CVT-10216

KLF4: APTO-253

Kinase inhibitor ^[3]

KIT: Imatinib; Nilotinib; Dasatinib; Sunitinib malate

BRAF: Encorafenib; Dabrafenib Mesylate; Vemurafenib

MEK: Binimetinib; Cobimetinib; Trametinib DMSO solvate

Immunopotentiation

Compound Library

FDA-approved Anticancer Drug Library

Anti-cancer Compound Library

Anti-cancer Compound Library-Ⅱ

Anti-cancer Metabolism Compound Library

Cambridge Cancer Compound Library

Small Molecule Immuno-Oncology Compound Library

Tyrosine Kinase Inhibitor Library

Angiogenesis Related compound Library

References

https://pubmed.ncbi.nlm.nih.gov/36199539/
https://pubmed.ncbi.nlm.nih.gov/31265892/
https://www.sciencedirect.com/science/article/pii/S0140673618315599#cesec40