For research use only. Not for use in humans.

Ponezumab (Anti-Amyloid Beta)

Synonyms: PF-04360365 Cat.No.A3014 Purity:99%

Ponezumab (Anti-Amyloid Beta) is a humanised IgG2 monoclonal antibody amyloid. It can be used in study of Alzheimer's disease. MW :145.66 KD.

Quality Control

Batch: Purity: 99% Protein concentration: 9.2mg/ml Endotoxin Level: ＜1EU/mg

Specificity

Name	Citation	Beta Amyloid	Others
DAPT	398	+++	Notch
RO4929097 (RG-4733)	124	+++	γ secretase,Notch
Semagacestat (LY450139)	22	+++	Notch
MK-0752	23	++++
Avagacestat (BMS-708163)	22	++++
LY2811376	19	++	BACE1
CRANAD-2	0	++
Hoechst 34580	1	+
Frentizole	0	+
Simufilam	0	✔
Ginsenoside Rg1	5	✔	NF-κB
Ginsenoside Re	1	✔	NF-κB,JNK
Tabersonine hydrochloride	0	✔
EUK 134	6	✔

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Ponezumab (Anti-Amyloid Beta) is a humanised IgG2 monoclonal antibody amyloid. It can be used in study of Alzheimer's disease. MW :145.66 KD.
References	[1] https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1016/j.jalz.2009.04.270

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	1178862-65-1
Isotype	Human IgG2SA
Source	CHO
Formulation	100 mM Pro-Ac, 20mM Arg, pH5.0
Storage (From the date of receipt)	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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