Home Biosimilar Antibodies Immunology & Inflammation Interleukins Netakimab (Anti-CTLA-8 / IL-17a)
For research use only. Not for use in humans.

Netakimab (Anti-CTLA-8 / IL-17a)

Synonyms: null

Netakimab (Anti-CTLA-8 / IL-17a) is a humanized monoclonal antibody against interleukin-17 (IL-17) with the potential to treat moderate to severe plaque psoriasis. MW: 145.74 KD.

Netakimab (Anti-CTLA-8 / IL-17a)

Quality Control

Batch: Purity: 99% Protein concentration: 6.017mg/ml Endotoxin Level: ＜1EU/mg
99

Specificity

Name Citation IL-6 IL-1 IL-8 IL-12 IL-10 IL-13 IL-2 Others
SKF-86002 1
JTE-607 Dihydrochloride 2 TNF-alpha
A-740003 2 rat P2X7 receptor,human P2X7 receptor
Apilimod mesylate 6 PIKfyve
MD2-TLR4-IN-1 2 TLR4,TNF-α
Danirixin (GSK1325756) 2 CXCR2
Resatorvid (TAK-242) 65 TLR4,NO,TNF-α
Apilimod (STA-5326) 19 PIKfyve
LMT-28 1
Atractylodin 0 NAAA
Triolein 0 ROS,MMP-1
Ac-YVAD-cmk 5
Diethyl phosphate 1
RCM-1 5 STAT6,FOXM1,β-catenin
Stylopine 0 COX-2,TNF-α,NO
Myrislignan 1 NF-κB,COX-2,iNOS
NE 52-QQ57 2 iNOS,TNF-α,PGE2
PKR-IN-C16 9 PKR
(3R,8S)-Falcarindiol 3 STAT,ERK,JNK
Gardenoside 1 P2X7 Receptor,P2X3 receptor,NF-κB
T-5224 23 c-Jun,c-Fos/AP-1,Adamts-5
IQ 3 1 TNF-α,JNK3,JNK1
Isuzinaxib (APX-115 free base) 2 TNFα,MCP-1/CCL2,NOX2
AUDA 1 p38,Smad3,TGF-β
SAR-20347 1 IFN-α,TYK2,JAK1
SU 5201 0
Madecassic acid 3 TNF-α,COX-2,iNOS
Homoplantaginin 1 NF-κB,IKKβ,TNF-α
2',5'-Dihydroxyacetophenone 1 NF-κB,ERK1/2,iNOS
Forsythoside B 0 NF-κB,TNF-alpha,IκB
Mulberroside A 0 NF-κB,Caspase-1,NALP3
Chelidonic acid 0 glutamate decarboxylase,Caspase-1,NF-κB
4-Methylesculetin 2 MPO
Muscone 4 TNF-α,NLRP3 inflammasome,NF-κB
Ossirene (AS101) 16
Methylthiouracil 1 ERK1/2,NF-κB,TNF-α
Expand to Check More
1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description
Netakimab (Anti-CTLA-8 / IL-17a) is a humanized monoclonal antibody against interleukin-17 (IL-17) with the potential to treat moderate to severe plaque psoriasis. MW: 145.74 KD.
References

Product Details

CAS No. 1796570-08-5
Molecular Weight 145.74
Isotype Human IgG1
Source CHO
Purification AKTA
Sterility 0.2 μM filtered
Formulation 100 mM Pro-Ac, 20mM Arg, pH5.0
Storage
(From the date of receipt)		 Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT07704190 NOT_YET_RECRUITING Cardiorenal Metabolic Syndrome; Atherosclerotic Cardiovascular Disease; Chronic Kidney Disease; Coronary Artery Disease; Hypertension; Type 2 Diabetes Mellitus; Peripheral Arterial Disease; Carotid Artery Stenosis Peking University Third Hospital 2026-07-15 PHASE4
NCT07554014 NOT_YET_RECRUITING Hidradenitis Suppurativa (HS) Second Affiliated Hospital, Zhejiang University, School of Medicine 2026-04-01 PHASE4
NCT06779097 NOT_YET_RECRUITING Drug: Vunakizumab (IL-17A inhibitor) Moderate to Severe Plaque Psoriasis Suzhou Suncadia Biopharmaceuticals Co., Ltd. 2025-02 PHASE4
NCT06881290 RECRUITING Drug: Vunakizumab (IL-17A inhibitor) Lupus Erythematosus, Systemic Chinese SLE Treatment And Research Group 2025-05-19 PHASE1
NCT06259890 RECRUITING Spondyloarthritis, Axial; Arthritis, Psoriatic Centre Hospitalier Universitaire de Besancon 2024-01-30
NCT07449156 NOT_YET_RECRUITING Drug: HB0043|Drug: Placebo Acne Vulgaris Shanghai Huaota Biopharmaceutical Co., Ltd. 2026-03-27 PHASE1; PHASE2

(data from https://clinicaltrials.gov, updated on 2026-07-15)

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Handling Instructions

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