Home GPCR & G Protein Ras inhibitor LY3537982 (KRAS G12C inhibitor 19) For research use only.

LY3537982 (KRAS G12C inhibitor 19)

LY3537982 (KRAS G12C inhibitor 19) is a highly selective and potent inhibitor of the  KRAS-G12C protein. LY3537982 selectively inhibits the growth of KRAS G12C mutant cells H23 G12C, H358 G12C, and H2122 G12C with IC50s of 1.04 nM, 1.16 nM, and 11.38 nM, respectively.

LY3537982 (KRAS G12C inhibitor 19) Chemical Structure

LY3537982 (KRAS G12C inhibitor 19) Chemical Structure

CAS No. 2649788-46-3

Purity & Quality Control

Batch: E143301 DMSO]100 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.01%
99.01

LY3537982 (KRAS G12C inhibitor 19) Related Products

Signaling Pathway

Ras Signaling Pathways

Ras Signaling Pathway

Biological Activity

Description LY3537982 (KRAS G12C inhibitor 19) is a highly selective and potent inhibitor of the  KRAS-G12C protein. LY3537982 selectively inhibits the growth of KRAS G12C mutant cells H23 G12C, H358 G12C, and H2122 G12C with IC50s of 1.04 nM, 1.16 nM, and 11.38 nM, respectively.
Targets
KRAS-G12C [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06235983 Recruiting
Advanced Solid Tumors
Eli Lilly and Company
 February 29 2024 Phase 1
NCT05901311 Completed
Healthy
Eli Lilly and Company|Loxo Oncology Inc.
 June 5 2023 Phase 1
NCT05860933 Completed
Healthy
Eli Lilly and Company|Loxo Oncology Inc.
 May 8 2023 Phase 1
NCT05824858 Completed
Healthy
Eli Lilly and Company|Loxo Oncology Inc.
 April 12 2023 Phase 1

Chemical Information & Solubility

Molecular Weight 528.96 Formula

C25H19ClF2N4O3S
CAS No. 2649788-46-3 SDF Download LY3537982 (KRAS G12C inhibitor 19) SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (189.05 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy LY3537982 (KRAS G12C inhibitor 19) | LY3537982 (KRAS G12C inhibitor 19) supplier | purchase LY3537982 (KRAS G12C inhibitor 19) | LY3537982 (KRAS G12C inhibitor 19) cost | LY3537982 (KRAS G12C inhibitor 19) manufacturer | order LY3537982 (KRAS G12C inhibitor 19) | LY3537982 (KRAS G12C inhibitor 19) distributor