For research use only. Not for use in humans.

Anti-PDGFRB / CD140b (IMC-2C5)

Synonyms: IMC-2C5 Cat.No.A3043 Purity:99%

Anti-PDGFRB / CD140b (IMC-2C5) is a fully human antagonistic antibody targeting PDGFRβ It enhances antitumor activity and antiangiogenic agents in the treatment of a broad range of human cancers. MW :145.06 KD.

Quality Control

Batch: A304301 Purity: 99% Protein concentration: 8.7mg/ml Endotoxin Level: ＜1EU/mg

Cited in Nature Medicine for its top-tier quality
COA
SDS
Datasheet

Specificity

Name	Citation	PDGFR	PDGFRα	PDGFRβ	Others
Foretinib	94		++++	+++	Met,KDR,Tie-2
Cediranib (AZD2171)	67		+++	++++	VEGFR2/KDR,c-Kit,VEGFR3/FLT4
Dovitinib (TKI-258)	52			+++	FLT3,c-Kit,VEGFR3/FLT4
Linifanib (ABT-869)	33			++	CSF-1R,VEGFR1/FLT1,FLT3
Crenolanib	99		++++	++++	FLT3
Masitinib	42		+	+	Kit,Lyn B,Abl1
Amuvatinib (MP-470)	21		++		c-RET,RAD51,c-Met
Motesanib Diphosphate (AMG-706)	12	+			VEGFR1,VEGFR2,VEGFR2/Flk1
Orantinib (SU6668)	21			+++
ENMD-2076	9		++		FLT3,RET,Aurora A
CP-673451	36		+++	++++
Ki8751	21		++		VEGFR2,c-Kit
Telatinib	5		+++		c-Kit,VEGFR3,VEGFR2
PP121	5	++++			Hck,VEGFR2,mTOR
MK-2461	4			+++	c-Met (M1250T),c-Met (Y1235D),c-Met (Y1230H)
Tyrphostin AG 1296	14	+			c-Kit (Swiss 3T3),FGFR (Swiss 3T3)
Agerafenib (CEP-32496)	6			++++	RET,LCK,c-Kit
Tyrphostin 9	1	+			EGFR
AG 825	0	+			ErbB2
JNJ-10198409	0		++	++++
Masitinib mesylate	0		+	+	FGFR3,FAK,human recombinant c-Kit
Flumatinib (HH-GV-678)	0			+	c-Abl,c-Kit
Seralutinib (GB002)	0		+++	+++
Ki20227	1			+	c-Fms,VEGFR2,c-Kit
Tyrphostin AG1433	0			+	VEGFR-2
SU14813	2			++++	VEGFR1,KIT,VEGFR2
Toceranib phosphate	1	++++			Flk-1/DFR
ON123300	4			+++	CDK4/CyclinD1,ARK5,RET
SU5402	24			+	VEGFR2,FGFR1
Dovitinib (TKI258) Lactate monohydrate	31			+++	FLT3,c-Kit,FGFR1
AZD2932	3			++++	Flt3,VEGFR-2,c-Kit
N-(p-Coumaroyl) Serotonin	0	✔
Vorolanib	0	✔			VEGFR
SKLB 610	2	✔			FGFR2,VEGFR2
AZD3229	0		✔		Kit
PDGFR inhibitor 1	4	✔			VEGFR2,c-Fms,Kit
Trapidil	8	✔
Sennoside B	0	✔

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Anti-PDGFRB / CD140b (IMC-2C5) is a fully human antagonistic antibody targeting PDGFRβ It enhances antitumor activity and antiangiogenic agents in the treatment of a broad range of human cancers. MW :145.06 KD.
References	[1] https://pubmed.ncbi.nlm.nih.gov/19484148/

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

Isotype	Human IgG1
Source	CHO
Formulation	100 mM Pro-Ac, 20mM Arg, pH5.0
Storage (From the date of receipt)	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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