Topoisomerase

A Novel Polyamino Acid Sulfur Dioxide Prodrug Synergistically Elevates ROS with β-lapachone in Cancer Treatment

38 views | Jan 12 2024

This groundbreaking study combines sulfur dioxide gas therapy and a specific ROS-inducing agent, β-lapachone, encapsulated in nanoparticles, demonstrating potent anticancer effects through oxidative stress induction in both in vitro and in vivo models. [Read the Full Post]

Prospects of Topoisomerase Inhibitors as Promising Anti-Cancer Agents

59 views | Dec 16 2023

The review underscores the significance of topoisomerase inhibitors, such as irinotecan and etoposide, in cancer treatment by disrupting DNA replication and inducing cell death, emphasizing their potential as crucial anti-cancer medications. [Read the Full Post]

Viability of selected microorganisms in parenteral preparations for novel systemic anti-cancer therapy

48 views | Nov 18 2023

**"This study reveals the persistence of viable pathogenic microorganisms in most aseptically prepared parenteral cancer therapy solutions, emphasizing the importance of strict aseptic conditions and careful consideration of antimicrobial activity when determining their shelf life."** [Read the Full Post]

Tamoxifen resistance induction results in the upregulation of ABCG2 expression and mitoxantrone resistance in MCF-7 breast cancer cells

114 views | Oct 07 2023

The study found that prolonged exposure of ER+ MCF-7 breast cancer cells to tamoxifen led to increased expression of the ABCG2 pump, associated with TAM resistance and potential cross-resistance to mitoxantrone. [Read the Full Post]

Norepinephrine as the Intrinsic Contributor to Contact Lens-Induced Pseudomonas aeruginosa Keratitis

122 views | Sep 11 2023

This study reveals that norepinephrine, acting through the β2-adrenergic receptor, promotes Pseudomonas aeruginosa keratitis during contact lens wear, suggesting potential therapeutic targets for treating the condition. [Read the Full Post]

Investigation of the impact of rosuvastatin and telmisartan in doxorubicin-induced acute cardiotoxicity

118 views | Apr 15 2023

The study found that pre-treatment with rosuvastatin and telmisartan, alone or in combination, showed significant cardio-protective effects against the acute cardiotoxicity induced by doxorubicin. [Read the Full Post]

Interplay of Breast Cancer Resistance Protein (Bcrp/Abcg2), Sex, and Fed State in Oral Pharmacokinetic Variability of Furosemide in Rats

42 views | Mar 23 2023

The study investigated the effect of Bcrp-mediated transport, sex, and fed state on the pharmacokinetics of FUR in rats and found that Bcrp inhibition increased FUR exposure and that sex differences in Bcrp and Oat abundance in the kidney could influence PK. [Read the Full Post]

Biweekly cetuximab in combination with capecitabine and oxaliplatin (XELOX) or irinotecan (XELIRI) in the first-line and second-line treatment of patients with RAS wild-type metastatic colorectal cancer

113 views | Mar 18 2023

The study found that biweekly cetuximab in combination with XELOX or XELIRI is well-tolerated and effective in patients with RAS wild-type metastatic colorectal cancer, with favorable outcomes observed. [Read the Full Post]

Effects of extended oral antibiotic prophylaxis on surgical site infections after instrumented spinal fusion: a cohort study of 901 patients with a minimum follow-up of 1 year

33 views | Mar 11 2023

Extended antibiotic prophylaxis is associated with a lower incidence of superficial surgical site infection in instrumented spine surgery. [Read the Full Post]

Camptothecin analogs in malignant gliomas: comparative analysis and characterization

70 views | Feb 14 2023

The authors compared and characterized several new classes of camptothecin analogs and found that 10,11-methylenedioxy class consistently demonstrated the greatest cytotoxicity and hold promise for more effective local antitumor treatments against malignant intracranial brain tumors. [Read the Full Post]