Home Neuronal Signaling GluR inhibitor IEM 1754 2HBr For research use only.

IEM 1754 2HBr

IEM 1754 2HBr is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM.

IEM 1754 2HBr Chemical Structure

IEM 1754 2HBr Chemical Structure

CAS No. 162831-31-4

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IEM 1754 2HBr Related Products

Signaling Pathway

GluR Signaling Pathways

GluR Signaling Pathway

Biological Activity

Description IEM 1754 2HBr is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM.
Targets
GluR1 [1] GluR3 [1]
6 μM 6 μM
In vitro
In vitro IEM 1754 is an adamantane derivative. IEM 1754 causes use- and voltage-dependent block of open channels of recombinant AMPA receptors. This antagonism is dependent on receptor subunit composition, channels gated by recombinant, homomeric GluR1 and GluR3 receptors exhibites a higher sensitivity to block than those gated by receptors containing edited GluR2 subunits. [1] IEM-1754 block of GluR2-containing AMPAR is enhanced by hyperpolarization in agreement with the classical single-exponential model. In contrast, the block of GluR2-lacking AMPAR is reduced by hyperpolarization. [2]

Chemical Information & Solubility

Molecular Weight 412.25 Formula

C16H30N2.2HBr
CAS No. 162831-31-4 SDF Download IEM 1754 2HBr SDF
Smiles C1C2CC3CC1CC(C2)(C3)CNCCCCCN.Br.Br
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 82 mg/mL ( (198.9 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 82 mg/mL

Ethanol : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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