Home Neuronal Signaling GluR activator Xanthurenic Acid For research use only.

Xanthurenic Acid

Synonyms: xanthurenate, 8-Hydroxykynurenic acid, 4,8-Dihydroxyquinaldic acid

Xanthurenic acid (xanthurenate, 8-Hydroxykynurenic acid, 4,8-Dihydroxyquinaldic acid), a molecule arising from tryptophan metabolism by transamination of 3-hydroxykynurenine, activates mGlu2/3 Metabotropic glutamate receptors (mGlu2 and mGlu3).

Xanthurenic Acid Chemical Structure

Xanthurenic Acid Chemical Structure

CAS No. 59-00-7

Purity & Quality Control

Batch: S477401 DMSO]7 mg/mL]false]]]false]]]false Purity: 99.99%
99.99

Xanthurenic Acid Related Products

Signaling Pathway

GluR Signaling Pathways

GluR Signaling Pathway

Biological Activity

Description Xanthurenic acid (xanthurenate, 8-Hydroxykynurenic acid, 4,8-Dihydroxyquinaldic acid), a molecule arising from tryptophan metabolism by transamination of 3-hydroxykynurenine, activates mGlu2/3 Metabotropic glutamate receptors (mGlu2 and mGlu3).
Targets
mGlu2 [1] mGlu3 [1]
In vitro
In vitro Xanthurenic acid (XA) is considered as a putative neurotransmitter in the CNS, being stored in synaptic vesicles and released by membrane depolarization in a Ca2+-dependent fashion. It is known to inhibit vesicular glutamate transporters (VGLUTs). In heterologous expression systems, Xanthurenic acid could activate both mGlu2 and mGlu3 receptors with high potency, but has no activity on mGlu4 and mGlu7 receptors[1]. Xanthurenic acid induces cell death associated with caspase-3, -8, and -9 activation, nuclear DNA cleavage, and cytochrome C release while not associated with cytoskeleton breakdown -- apoptosis induced by xanthurenic acid does not cause cytoskeleton depolymerization[2].
Cell Research Cell lines VSMC
Concentrations 5 μg/ml
Incubation Time one week
Method --
In Vivo
In vivo Systemic administration of Xanthurenic acid in mice produces antipsychotic-like effects in the MK-801-induced model of hyperactivity and peripheral xanthurenic acid can cross the blood-brain barrier, influence the activity of brain regions that are involved in the pathophysiology of schizophrenia[1].
Animal Research Animal Models Six to eight week-old male C57BL/6J mice
Dosages 30 or 60 mg/kg
Administration i.p.

Chemical Information & Solubility

Molecular Weight 205.17 Formula

C10H7NO4
CAS No. 59-00-7 SDF Download Xanthurenic Acid SDF
Smiles C1=CC2=C(C(=C1)O)NC(=CC2=O)C(=O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 7 mg/mL ( (34.11 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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