Elezanumab (Anti-RGMA)

Synonyms: ABT-555, AE12-1Y-QL

Catalog No.A2370 Purity:≥99%

Elezanumab (Anti-RGMA) is a human monoclonal antibody that selectively targets repulsive guidance molecule A (RGMa). Elezanumab potently inhibited RGMa mediated BMP signalling via the SMAD1/5/8 pathway with IC50 of 97 pM. MW: 146.44 kD.

Purity & Quality Control

≥99

Choose Selective TGF-beta/Smad Inhibitors

Name	Citation	ALK1	ALK2	ALK3	ALK4	TGFβRI/ALK5	ALK6	TGFβRII	TGF-β	ALK7	Others
SB431542	716					+
LDN-193189	243	++++	++++	+++			+++
Galunisertib (LY2157299)	184					+
LY2109761	130					++		+
SB525334	110					+++
SB505124	34				+	++
GW788388	24					++
LY364947	49					+		+			RIPK2,CK1δ,MLK-7K
RepSox (E-616452)	70					+++
LDN-193189 2HCl	95	++++	++++	+++			+++
K02288	24	++++	++++	++			+++
TGFβRI-IN-3	2					++++
R-268712	0					++++
BIBF-0775	0					++
TP0427736 HCl	6					+++
A-83-01	46				++	+++				+++
LDN-214117	4		++
SD-208	21					++
Vactosertib (TEW-7197)	26				+++	+++
ML347	5	++	++
LDN-212854	7	++++	++++	+	+	+
DMH1	50		+
Dorsomorphin 2HCl		✔								AMPK
PF-06952229					✔
Ginsenoside Rh4								✔
SIS3									✔
AUDA								✔		TNF-α,IL-1β,MMP-9
PD 169316								✔		Activin A,Enterovirus71,p38 MAPK
TA-02							✔			p38 MAPK
ITD-1								✔
LY 3200882					✔
Alantolactone									✔	STAT3
Halofuginone									✔	prolyl-tRNA synthetase
SIS3 HCl									✔
Dorsomorphin		✔								AMPK
Hesperetin								✔		Histamine receptor

Expand to Check More

1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Biological Activity

Description	Elezanumab (Anti-RGMA) is a human monoclonal antibody that selectively targets repulsive guidance molecule A (RGMa). Elezanumab potently inhibited RGMa mediated BMP signalling via the SMAD1/5/8 pathway with IC50 of 97 pM. MW: 146.44 kD.

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	1791416-49-3
Molecular Weight	146.44 kDa
Isotype	Human IgG1
Source	CHO
Purification	AKTA
Sterility	0.2 μM filtered
Formulation	100mMPro-Ac,20mMArg-Ac，pH5.0
Storage (From the date of receipt)	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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