Home Neuronal Signaling 5-HT Receptor agonist Cisapride (R 51619) For research use only.

Cisapride (R 51619)

Synonyms: Kaudalit, Kinestase, Prepulsid, Presid, Pridesia, Propulsid

Cisapride (R 51619, Kaudalit, Kinestase, Prepulsid, Presid, Pridesia, Propulsid) is a nonselective 5-HT4 receptor agonist with gastroprokinetic effects.

Cisapride (R 51619) Chemical Structure

Cisapride (R 51619) Chemical Structure

CAS No. 81098-60-4

Purity & Quality Control

Cisapride (R 51619) Related Products

Signaling Pathway

5-HT Receptor Signaling Pathways

5-HT Receptor Signaling Pathway

Biological Activity

Description Cisapride (R 51619, Kaudalit, Kinestase, Prepulsid, Presid, Pridesia, Propulsid) is a nonselective 5-HT4 receptor agonist with gastroprokinetic effects.
Targets
hERG channel [1] 5-HT4 receptor [1]
9.4 nM 140 nM(EC50)
In vitro
In vitro Cisapride is a 5-HT4 receptor agonist, also a hERG blockers[1]. It is widely used for the treatment of gastrointestinal motility dysfunctions, such as gastroesophageal reflux disorder (GERD), chronic intestinal pseudo-obstruction, and slow-transit constipation gastroparesis. Cisapride works by promoting gastrointestinal motility through stimulating the release of intestinal acetylcholine from muscarinic receptors. Cisapride inhibits Kv 4.3 channels that are stably expressed in Chinese hamster ovary (CEO) cells as well as the current in L-type Ca2+ channels of ventricular myocytes. Cisapride inhibited Kv channel current in a concentration-dependent manner independent of its own function as a selective serotonin 5-HT4-receptor agonist[2].

Chemical Information & Solubility

Molecular Weight 465.95 Formula

C23H29ClFN3O4
CAS No. 81098-60-4 SDF --
Smiles COC1CN(CCC1NC(=O)C2=CC(=C(C=C2OC)N)Cl)CCCOC3=CC=C(C=C3)F
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 93 mg/mL ( (199.59 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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