Home Neuronal Signaling 5-HT Receptor antagonist SB269970 HCl For research use only.

SB269970 HCl

SB269970 HCl is a hydrochloride salt form of SB-269970, which is a 5-HT7 receptor antagonist with pKi of 8.3, exhibits >50-fold selectivity against other receptors.

SB269970 HCl Chemical Structure

SB269970 HCl Chemical Structure

CAS No. 261901-57-9

Purity & Quality Control

Batch: S284901 DMSO]11 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.62%
99.62

SB269970 HCl Related Products

Signaling Pathway

5-HT Receptor Signaling Pathways

5-HT Receptor Signaling Pathway

Biological Activity

Description SB269970 HCl is a hydrochloride salt form of SB-269970, which is a 5-HT7 receptor antagonist with pKi of 8.3, exhibits >50-fold selectivity against other receptors.
Features A hydrochloride salt form of SB-269970 which is a potent 5-HT 7 receptor antagonist.
Targets
5-HT7 [1]
8.3(pKi)
In vitro
In vitro SB-269970 inhibits 5-CT-stimulated adenylyl cyclase activity in guinea-pig hippocampal membranes. SB-269970 (0.03 μM, 0.1 μM, 0.3 μM and 1 μM) produces a concentration-related rightward-shift of the 5-CT concentration-response curve with no significant alteration in the maximal response to 5-CT. [1] SB-269970 (1 μM) has any effect on 5-HT efflux when superfused alone. [2]
In Vivo
In vivo SB-269970 (10 mg/kg and 30 mg/kg) significantly reduces the effects of amphetamine by 25 and 27%, respectively, and blocks the effects of ketamine by 38% (10 mg/kg) and 30% (30 mg/kg). SB-269970 significantly reduces amphetamine-induced hyperactivity in wild-type mice and is without effects in 5-HT7 knockout mice. Systemic administration of SB-269970 (30 mg/kg) significantly reverses amphetamine disruption of PPI and did not enhance PPI by itself compared to control. [3] SB-269970 significantly reverses the deficits induced by MK-801, but not by scopolamine. SB-269970 normalizes MK-801-induced glutamate but not dopamine release in the cortex. [4] SB-269970 (in one medium dose of 0.5 or 1 mg/kg) exerts a specific antianxiety-like effect in the Vogel drinking test in rats, in the elevated plus-maze test in rats and in the four-plate test in mice. Moreover, SB-269970 (in one medium dose of 5 or 10 mg/kg) reveals antidepressant-like activity in the forced swimming and the tail suspension tests in mice. [5] SB-269970 at doses of 0.3, 1 and 3 μg exhibits an anticonflict effect which is weaker than that of diazepam (40 μg), whereas SB-269970 at doses of 3 and 10 μg had marked anti-immobility action comparable to that of imipramine (0.1 μg). [6]
Animal Research Animal Models C57BL6/J mice
Dosages 10 mg/kg, 30 mg/kg
Administration i.p.

Chemical Information & Solubility

Molecular Weight 388.95 Formula

C18H28N2O3S.HCl
CAS No. 261901-57-9 SDF Download SB269970 HCl SDF
Smiles CC1CCN(CC1)CCC2CCCN2S(=O)(=O)C3=CC=CC(=C3)O.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 11 mg/mL ( (28.28 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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