Home GPCR & G Protein SGLT inhibitor - ATPase inhibitor Phlorizin For research use only.

Phlorizin

Synonyms: Phloridzin

Phlorizin (Phloridzin) is a dihydrochalcone found in the bark of pear (Pyrus communis), apple, cherry and other fruit trees. Phlorizin is a non-selective SGLT inhibitor with Ki of 300 nM and 39 nM for hSGLT1 and hSGLT2, respectively. Phlorizin is also a Na+/K+-ATPase inhibitor.

Phlorizin Chemical Structure

Phlorizin Chemical Structure

CAS No. 60-81-1

Purity & Quality Control

Phlorizin Related Products

Signaling Pathway

SGLT Signaling Pathways

SGLT Signaling Pathway

Biological Activity

Description Phlorizin (Phloridzin) is a dihydrochalcone found in the bark of pear (Pyrus communis), apple, cherry and other fruit trees. Phlorizin is a non-selective SGLT inhibitor with Ki of 300 nM and 39 nM for hSGLT1 and hSGLT2, respectively. Phlorizin is also a Na+/K+-ATPase inhibitor.
Targets
Na+/K+-ATPase [4] Na+/K+-ATPase [4] hSGLT2 [3]
(Cell-free assay)		 hSGLT1 [3]
(Cell-free assay)
39 nM(Ki) 300 nM(Ki)
In vitro
In vitro

Phlorizin is a dihydrochalcone found in the bark of pear (Pyrus communis), apple, cherry and other fruit trees. Phlorizin is a competitive inhibitor of SGLT1 and SGLT2; this reduces renal glucose transport, lowering the amount of glucose in the blood. [1] Phlorizin's principal pharmacological action is to produce renal glycosuria and block intestinal glucose absorption through inhibition of the sodium-glucose symporters located in the proximal renal tubule and mucosa of the small intestine which benefits the treatment of diabetes, obesity, and stress hyperglycemia. [2]

Chemical Information & Solubility

Molecular Weight 436.41 Formula

C21H24O10
CAS No. 60-81-1 SDF Download Phlorizin SDF
Smiles C1=CC(=CC=C1CCC(=O)C2=C(C=C(C=C2OC3C(C(C(C(O3)CO)O)O)O)O)O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 87 mg/mL ( (199.35 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 87 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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