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SGLT

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All (16)
SGLT Inhibitors (16)
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Catalog No.	Product Name	Information	Product Use Citations
S1548	Dapagliflozin	Dapagliflozin is a potent and selective hSGLT2 inhibitor with EC50 of 1.1 nM, exhibiting 1200-fold selectivity over hSGLT1. Phase 4.	Eur Heart J, 2024, 31:ehae472. Cardiovasc Diabetol, 2024, 23(1):380 J Cell Mol Med, 2024, 28(6):e18176
S2760	Canagliflozin (JNJ 28431754)	Canagliflozin (TA 7284, JNJ 28431754) is a highly potent and selective SGLT2 inhibitor for hSGLT2 with IC50 of 2.2 nM in a cell-free assay, exhibits 413-fold selectivity over hSGLT1.	Redox Biol, 2024, 71:103103 J Clin Invest, 2023, 133(1)e154754 Clin Exp Hypertens, 2023, 10.1080/10641963.2023.2278205
S8022	Empagliflozin	Empagliflozin is a potent and selective SGLT-2 inhibitor with IC50 of 3.1 nM, exhibits >300-fold selectivity over SGLT-1, 4, 5 and 6. Phase 3.	Redox Biol, 2024, 69:103010 Arch Biochem Biophys, 2024, 754:109958 J Clin Invest, 2023, 133(8)e164610
S8103	Sotagliflozin	Sotagliflozin is an oral dual SGLT1/SGLT2 inhibitor with IC50 of 36 nM and 1.8 nM, respectively. Phase 3.	Cell Rep, 2024, 43(2):113675 Front Endocrinol (Lausanne), 2023, 14:1069715 Front Endocrinol (Lausanne), 2023, 14:1069715
S2343	Phlorizin	Phlorizin (Phloridzin) is a dihydrochalcone found in the bark of pear (Pyrus communis), apple, cherry and other fruit trees. Phlorizin is a non-selective SGLT inhibitor with Ki of 300 nM and 39 nM for hSGLT1 and hSGLT2, respectively. Phlorizin is also a Na+/K+-ATPase inhibitor.	Mol Ther Methods Clin Dev, 2022, 24:11-19 J Ginseng Res, 2022, 46(5):700-709 J Med Virol, 2019, 91(8):1440-1447
S2342	Phloretin (RJC 02792)	Phloretin (RJC 02792, NSC 407292, Dihydronaringenin) is a dihydrochalcone found in apple tree leaves, which shows beneficial effects on diabetes.	Br J Pharmacol, 2022, 10.1111/bph.15896 Food Funct, 2020, 10.1039/d0fo02362k J Med Virol, 2019, 91(8):1440-1447
S5901	Canagliflozin hemihydrate	Canagliflozin hemihydrate is the hemihydrate form of canagliflozin, which is a SGLT2 inhibitor with IC50 of 2.2 nM for hSGLT2 in a cell-free assay, exhibits 413-fold selectivity over hSGLT1.	Front Pharmacol, 2022, 13:848310 Yonsei Med J, 2022, 63(7):619-631 Cell Death Dis, 2018, 9(2):226
S5566	Dapagliflozin propanediol monohydrate	Dapagliflozin propanediol belongs to the class of orally administered antidiabetic agents designated as sodiumglucose cotransporter 2 (SGLT2) inhibitors.	Am J Physiol Renal Physiol, 2019, 316(5):F1078-F1089
S8558	Tofogliflozin(CSG 452)	Tofogliflozin (CSG 452) is a novel sodium-glucose co-transporter 2(SGLT2) inhibitor with IC50 values of 2.9 nM and 8444 nM for hSGLT2 and hSGLT1, respectively.
S0994	Ipragliflozin L-Proline	Ipragliflozin L-Proline is an orally active and selective inhibitor of SGLT2 with IC50 of 7.38 nM, 6.73 nM and 5.64 nM for human SGLT2, rat SGLT2 and mouse SGLT2, respectively.
S8637	Ipragliflozin (ASP1941)	Ipragliflozin (ASP1941) is a highly selective sodium-glucose cotransporter 2 (SGLT2) inhibitor with an IC50 value of 7.4 nM for hSGLT2 and a 254-fold selectivity versus SGLT1.
S8938	KGA-2727	KGA-2727 is a potent, selective, high-affinity inhibitor of sodium glucose cotransporter 1 (SGLT1) with Ki of 97.4 nM and 43.5 nM for human SGLT1 and rat SGLT1, respectively. The selectivity ratios (Ki for SGLT2/Ki for SGLT1) of KGA-2727 are 140 (human) and 390 (rat). KGA-2727 exhibits antidiabetic efficacy in rodent models.
S8939	Mizagliflozin (KWA 0711)	Mizagliflozin (KWA 0711) is a novel, potent, selective sodium glucose co-transporter 1 (SGLT1) inhibitor with Ki of 27 nM for human SGLT1. The selectivity ratio (Ki value for human SGLT2/Ki value for human SGLT1) of mizagliflozin is 303. Mizagliflozin shows the potential use for the amelioration of chronic constipation.
S5413	Ertugliflozin	Ertugliflozin (MK-8835, PF-04971729) is a potent and selective sodium-dependent glucose cotransporter 2 inhibitor with IC50 values of 0.877 nM for h-SGLT2 and 1000-fold higher for h-SGLT1.
E0141	Bexagliflozin (EGT1442)	Bexagliflozin (EGT1442, EGT-0001442, THR-1442) is a potent and selective SGLT2 inhibitor with an IC50 of 2 nM.
S4431	Ertugliflozin L-pyroglutamic acid	Ertugliflozin (MK-8835, PF-04971729) L-pyroglutamic acid is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2) with IC50 of 0.877 nM for h-SGLT2. Ertugliflozin has the potential for the treatment of type 2 diabetes mellitus.
S1548	Dapagliflozin	Dapagliflozin is a potent and selective hSGLT2 inhibitor with EC50 of 1.1 nM, exhibiting 1200-fold selectivity over hSGLT1. Phase 4.	Eur Heart J, 2024, 31:ehae472. Cardiovasc Diabetol, 2024, 23(1):380 J Cell Mol Med, 2024, 28(6):e18176
S2760	Canagliflozin (JNJ 28431754)	Canagliflozin (TA 7284, JNJ 28431754) is a highly potent and selective SGLT2 inhibitor for hSGLT2 with IC50 of 2.2 nM in a cell-free assay, exhibits 413-fold selectivity over hSGLT1.	Redox Biol, 2024, 71:103103 J Clin Invest, 2023, 133(1)e154754 Clin Exp Hypertens, 2023, 10.1080/10641963.2023.2278205
S8022	Empagliflozin	Empagliflozin is a potent and selective SGLT-2 inhibitor with IC50 of 3.1 nM, exhibits >300-fold selectivity over SGLT-1, 4, 5 and 6. Phase 3.	Redox Biol, 2024, 69:103010 Arch Biochem Biophys, 2024, 754:109958 J Clin Invest, 2023, 133(8)e164610
S8103	Sotagliflozin	Sotagliflozin is an oral dual SGLT1/SGLT2 inhibitor with IC50 of 36 nM and 1.8 nM, respectively. Phase 3.	Cell Rep, 2024, 43(2):113675 Front Endocrinol (Lausanne), 2023, 14:1069715 Front Endocrinol (Lausanne), 2023, 14:1069715
S2343	Phlorizin	Phlorizin (Phloridzin) is a dihydrochalcone found in the bark of pear (Pyrus communis), apple, cherry and other fruit trees. Phlorizin is a non-selective SGLT inhibitor with Ki of 300 nM and 39 nM for hSGLT1 and hSGLT2, respectively. Phlorizin is also a Na+/K+-ATPase inhibitor.	Mol Ther Methods Clin Dev, 2022, 24:11-19 J Ginseng Res, 2022, 46(5):700-709 J Med Virol, 2019, 91(8):1440-1447
S2342	Phloretin (RJC 02792)	Phloretin (RJC 02792, NSC 407292, Dihydronaringenin) is a dihydrochalcone found in apple tree leaves, which shows beneficial effects on diabetes.	Br J Pharmacol, 2022, 10.1111/bph.15896 Food Funct, 2020, 10.1039/d0fo02362k J Med Virol, 2019, 91(8):1440-1447
S5901	Canagliflozin hemihydrate	Canagliflozin hemihydrate is the hemihydrate form of canagliflozin, which is a SGLT2 inhibitor with IC50 of 2.2 nM for hSGLT2 in a cell-free assay, exhibits 413-fold selectivity over hSGLT1.	Front Pharmacol, 2022, 13:848310 Yonsei Med J, 2022, 63(7):619-631 Cell Death Dis, 2018, 9(2):226
S5566	Dapagliflozin propanediol monohydrate	Dapagliflozin propanediol belongs to the class of orally administered antidiabetic agents designated as sodiumglucose cotransporter 2 (SGLT2) inhibitors.	Am J Physiol Renal Physiol, 2019, 316(5):F1078-F1089
S8558	Tofogliflozin(CSG 452)	Tofogliflozin (CSG 452) is a novel sodium-glucose co-transporter 2(SGLT2) inhibitor with IC50 values of 2.9 nM and 8444 nM for hSGLT2 and hSGLT1, respectively.
S0994	Ipragliflozin L-Proline	Ipragliflozin L-Proline is an orally active and selective inhibitor of SGLT2 with IC50 of 7.38 nM, 6.73 nM and 5.64 nM for human SGLT2, rat SGLT2 and mouse SGLT2, respectively.
S8637	Ipragliflozin (ASP1941)	Ipragliflozin (ASP1941) is a highly selective sodium-glucose cotransporter 2 (SGLT2) inhibitor with an IC50 value of 7.4 nM for hSGLT2 and a 254-fold selectivity versus SGLT1.
S8938	KGA-2727	KGA-2727 is a potent, selective, high-affinity inhibitor of sodium glucose cotransporter 1 (SGLT1) with Ki of 97.4 nM and 43.5 nM for human SGLT1 and rat SGLT1, respectively. The selectivity ratios (Ki for SGLT2/Ki for SGLT1) of KGA-2727 are 140 (human) and 390 (rat). KGA-2727 exhibits antidiabetic efficacy in rodent models.
S8939	Mizagliflozin (KWA 0711)	Mizagliflozin (KWA 0711) is a novel, potent, selective sodium glucose co-transporter 1 (SGLT1) inhibitor with Ki of 27 nM for human SGLT1. The selectivity ratio (Ki value for human SGLT2/Ki value for human SGLT1) of mizagliflozin is 303. Mizagliflozin shows the potential use for the amelioration of chronic constipation.
S5413	Ertugliflozin	Ertugliflozin (MK-8835, PF-04971729) is a potent and selective sodium-dependent glucose cotransporter 2 inhibitor with IC50 values of 0.877 nM for h-SGLT2 and 1000-fold higher for h-SGLT1.
E0141	Bexagliflozin (EGT1442)	Bexagliflozin (EGT1442, EGT-0001442, THR-1442) is a potent and selective SGLT2 inhibitor with an IC50 of 2 nM.
S4431	Ertugliflozin L-pyroglutamic acid	Ertugliflozin (MK-8835, PF-04971729) L-pyroglutamic acid is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2) with IC50 of 0.877 nM for h-SGLT2. Ertugliflozin has the potential for the treatment of type 2 diabetes mellitus.

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