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Potassium Channel

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Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S1979 Amiodarone HCl Amiodarone HCl is a sodium/potassium-ATPase inhibitor and an autophagy activator, used to treat various types of cardiac dysrhythmias.
Cancer Cell, 2025, 43(4):776-796.e14
J Immunother Cancer, 2024, 12(11)e009805
Cell Rep Methods, 2023, 3(4):100440
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S2443 Tolbutamide (HLS 831) Tolbutamide (HLS 831) is an inhibitor of potassium channel, used for type II diabetes.
Adv Healthc Mater, 2024, e2303785.
iScience, 2024, 27(10):110862
UNIVERSITY OF PÉCS, 2023,
S1716 Glyburide (Glibenclamide) Glyburide (Glibenclamide), a known blocker of vascular ATP-sensitive K+ channels (KATP), is used in the treatment of type 2 diabetes.
Antioxidants, 2025, 1487
Computers in Biology and Medicine, 2024, 171:108163
Cell Chem Biol, 2023, S2451-9456(23)00335-5
E4788 Nigericin Nigericin is an antibiotic derived from Streptomyces hygroscopicus that acts as a K+/H+ ionophore, which causes the efflux of potassium from the cell and, thus, influences the mitochondria membrane potential. It also induces pyroptosis in macrophages by activating NLRP3 inflammasome.
International Journal of Molecular Sciences, March 20, 2026, 2841
Cancer Research, March 2, 2023, 720-734
Oxidative Medicine and Cellular Longevity, January 5, 2022, 1733834
S1658 Dofetilide Dofetilide (UK-68798) is a selective potassium channel ((hERG)) blocker, used as a Class III antiarrhythmic drug.
Current Directions in Biomedical Engineering, 2025 Sep, 270-273
Autophagy, 2025 Apr 4, 1945-1961
Autophagy, 2025, 1-17.
S1160 TRAM-34 TRAM-34 (Triarylmethane-34) is a selective and potent inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1) with Kd of 20 nM, 200- to 1500-fold selective over other ion channels, and does not block cytochrome P450.
Cancer Research, 2026, 1194-1214
Nat Commun, 2024, 15(1):7566
Biomedicine & Pharmacotherapy, 2023, 115635
S2114 Dronedarone HCl Dronedarone HCl (SR33589) is a multichannel blocker targeting potassium channel, sodium channel and calcium channel, used as an antiarrhythmic drug for treatment of atrial fibrillation (AF).
Oncology Letters, 2025, nan
Korean Circulation Journal, 2024, 172-186
Cancers (Basel), 2022, 14(19)4883
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S1971 Nicorandil Nicorandil (SG-75) is a potassium channel activator, and stimulates guanylate cyclase to increase formation of cyclic GMP (cGMP).
J Immunother Cancer, 2024, 12(11)e009805
J Cardiovasc Pharmacol Ther, 2022, 27:10742484221088655
BMC Cardiovasc Disord, 2021, 21(1):302
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S2825 ML133 HCl ML133 HCl is a selective potassium channel inhibitor for Kir2.1 with IC50 of 1.8 μM (pH 7.4) and 290 nM (pH 8.5), has no effect on Kir1.1 and weak activity for Kir4.1 and Kir7.1.
American Journal of Physiology-Cell Physiology, 2025, C413-C425
Cell Mol Immunol, 2022, 19(8):925-943
Cellular & Molecular Immunology, 2022, 925–943
S2562 Hydralazine HCl Hydralazine HCl is a hydrochloride salt of hydralazine, which is a direct-acting smooth muscle relaxant used to treat hypertension by acting as a vasodilator primarily in arteries and arterioles.
eLife, May 2024, e98221
Acta Pharmaceutica Sinica B, January 2023, 142-156
J Immunother Cancer, 2024, 12(11)e009805

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